Monitoring osteoporosis therapy: Can FRAX help assessing success or failure in achieving treatment goals?

Table 1 Mean of the proximal femur bone mineral density, predicted 10-year major osteoporotic fracture and hip fracture probability estimated for all patients at baseline, 2-year and 5-year

	At baselinemean ± SD	2-yr of treatmentmean ± SD	5-yr of treatmentmean ± SD
Total proximal femur BMD	0.553 ± 0.69	0.574 ± 0.06	0.579 ± 0.04
T-score	-2.75 ± 0.61	-2.32 ± 0.45	-1.46 ± 0.35
FRAX 10-yr major osteoporosis fracture risk	21.43 ± 7.56	14.81 ± 4.79	9.67 ± 2.92
FRAX 10-yr hip fracture risk	7.11 ± 4.55	4.4 ± 2.62	4.11 ± 4.55

BMD: Bone mineral density; FRAX: The World Health Organization fracture risk assessment tool.

Table 2 Prevalence of low trauma fractures at baseline in comparison to its incidence at 2-year and 5-year of observation

	At baseline		At 2-yr		At 5 yr
	Frequency	Percentage	Frequency	Percentage	Frequency	Percentage
No fracture	292	50.4	481	83.1	552	95.3
Low trauma fracture	287	49.36	98	16.9	27	4.7

Table 3 Correlation of the World Health Organization fracture risk assessment tool stratified major osteoporotic and hip fracture 10-year probability with the total proximal femur bone mineral density measurement

	BMD total proximal femur at baseline	BMD total proximal femur at 2-yr	BMD total proximal femur at 5-yr
FRAX 10-yr major osteoporosis fracture risk probability	-0.551b	-0.449b	-0.479b
FRAX 10-yr hip fracture risk probability	-0.741b	-0.547b	-0.584b
Change in FRAX 10-yr major osteoporosis fracture probability at 2-yr		-0.459b
Change in FRAX 10-yr hip fracture probability at 2-yr		-0.557b
Major osteoporosis fracture probability at 5-yr			-0.489b
Change in FRAX 10-yr hip fracture probability at 5-yr			-0.594b

^bP < 0.01, BMD total proximal femur at 2-yr and 5-yr vs BMD total proximal femur at baseline. BMD: Bone mineral density; FRAX: The World Health Organization fracture risk assessment tool.