Copyright
©The Author(s) 2016.
Figure 1 Schematic representation of possible role of leptin in the pathogenesis of psoriatic, rheumatoid and osteo-arthritis.
Leptin levels regulate release of pro-inflammatory cytokines: IL-1, IL-6, IFN-γ, TNF-α, and IL-23/IL-17, very well-known pro-inflammatory mediators affecting joint cartilage, chondrocyte loss and apoptosis. RA: Rheumatoid arthritis; OA: Osteoarthritis; PsA: Psoriatic arthritis; TNF-α: Tumor necrosis factor-α; IL: Interleukin; IFN: Interferon.
- Citation: Mounessa J, Voloshyna I, Glass AD, Reiss AB. Role of leptin in the progression of psoriatic, rheumatoid and osteoarthritis. World J Rheumatol 2016; 6(1): 9-15
- URL: https://www.wjgnet.com/2220-3214/full/v6/i1/9.htm
- DOI: https://dx.doi.org/10.5499/wjr.v6.i1.9