Review of the genetic basis of emotion dysregulation in children and adolescents

Table 1 Summary of emotion dysregulation genetic correlates in children and adolescents

Genetic neural correlates
5-HTTLPR low-expressing allele carriers
Pacheco et al[13]	Reduced white matter connectivity/density in uncinate fasciculus
Spangler et al[16]	Increased risk for development of disorganized attachment pattern
Gotlib et al[21]	Prolonged cortisol activity after a stressor
COMT Val156Met(rs460) Met Allele Carriers
Boettinger et al[27]	Greater emotion dysregulation associated with dopaminergic systems
Waugh et al[24]
Egan et al[25]
Tunbridge et al[26]
DRD2/ANKK1 Polymorphism
Althaus et al[28]	5-HTTLPR S allele may predispose to (performance) anxiety, while DRD2 Taq1 A allele may predispose to the reward deficiency syndrome.