Hemispheric asymmetries and network dysfunctions in adolescent depression: A neuroimaging study using resting-state functional magnetic resonance imaging

Table 1 Demographics and clinical profiles of adolescent depression and healthy controls, mean ± SD

Item	Depression group (n = 74)	HCs group (n = 59)	t/χ2 value	P value
Gender (F/M)	50/24	40/19	0a	1.00
Age (years)	14.99 ± 1.49	15.02 ± 2.00	-0.10b	0.92
Education (years)	9.09 ± 1.54	8.92 ± 2.09	0.57b	0.57
HAMD	26.16 ± 5.77	0.90 ± 1.67	32.58b	< 0.001

^aχ² test.

^bTwo sample t-test.

HCs: Healthy controls; F: Female; M: Male; HAMD: Hamilton depression rating scale.

Table 2 Functional connectivity differences across key brain networks in adolescents with depression and healthy controls groups

Item	X	Y	Z	t value	P value (FDR)
LH_Visual Network_14	120	19	135	4.389	< 0.001
RH_Visual Network_11	124	18	140	-3.106	0.002
LH_Default Mode Network_PFC_9	205	63	82	3.370	< 0.001
RH_Default Mode Network_Par_3	209	62	80	-5.397	< 0.001
RH_Default Mode Network_PFCdPFCm_5	208	62	81	-5.339	< 0.001
RH_Dorsal Attention Network_Post_9	4	119	21	3.119	0.002
RH_Salience Network_Med_1	200	57	250	-3.496	< 0.001
LH_Somatomotor Network_8	70	130	182	-3.149	0.002
LH_Somatomotor Network_11	70	130	185	-3.325	0.001

LH: Left hemisphere; RH: Right hemisphere; FDR: False discovery rate.