Global trends of purinergic receptors and depression: A bibliometric analysis from 2003 to 2023

Table 1 Search queries

Set	Results	Search query
1	450751	TS = [(Depression) OR (Depressive Symptom) OR (Depressive Disorder) OR (Emotional Depression) OR (Depressive Syndrome)]
2	261873	TS = [(Purinergic Signaling) OR (P1 Receptor) OR (P2 Receptor) OR (P2X) OR (P2Y) OR (Adenosine) OR (ATP) OR (ADP) OR (UTP) OR (UDP)]
3	2965	1 AND 2

ATP: Adenosine triphosphate; ADP: Adenosine diphosphate; UTP: Uridine triphosphate; UDP: Uridine diphosphate.

Table 2 Top 10 Countries with the most publications and centrality related to purinergic receptors in depression, n (%)

Rank	Countries	Publications (%)	Rank	Countries	Centrality
1	China	89 (36.03)	1	United Kingdom	0.45
2	United States	42 (17.00)	2	United States	0.4
3	Germany	32 (12.96)	3	Germany	0.36
4	Brazil	25 (10.12)	4	China	0.15
5	United Kingdom	22 (8.91)	5	Australia	0.14
6	Australia	14 (5.67)	6	Brazil	0.13
7	Italy	11 (4.45)	7	Italy	0.12
8	Hungary	8 (3.24)	8	Iran	0.09
9	Japan	8 (3.24)	9	Canada	0.06
10	Spain	8 (3.24)	10	Austria	0.03

Table 3 Top 10 frequency and centrality of institutions associated with purinergic receptors in depression

Rank	Institutions	Frequency	Rank	Institutions	Centrality
1	Southern Medical University China	11	1	Southern Medical University China	0.13
2	Max Planck Society	10	2	Jinan University	0.11
3	Universidade Federal de Santa Catarina	9	3	National Institutes of Health United States	0.1
4	Nanchang University	8	4	Max Planck Society	0.09
5	Semmelweis University	8	5	Academy of Military Medical Sciences China	0.09
6	Chengdu University of Traditional Chinese Medicine	7	6	RWTH Aachen University	0.09
7	Universidade de Sao Paulo	7	7	Helmholtz Association	0.07
8	National Institutes of Health United States	7	8	Universidade de Coimbra	0.06
9	Aarhus University	6	9	Harvard University	0.04
10	University of Manchester	6	10	Harvard Medical School	0.04

Table 4 Top 10 authors and co-cited authors in the field of purinergic receptors in depression

Rank	Authors	Publications	Rank	Authors	Citations
1	Liang SS	6	1	Burnstock G	162
2	Rodrigues, Ana Lucia S	6	2	Kaster MP	91
3	Deussing, Jan M	5	3	Maes M	68
4	Tang Y	5	4	Cunha RA	65
5	Poleszak E	4	5	Bhattacharya A	65
6	Serchov T	4	6	Salamone JD	63
7	Szopa A	4	7	Csolle C	61
8	Li SJ	4	8	Fredholm BB	60
9	Cunha RA	4	9	Illes P	59
10	Szekely A	4	10	Iwata M	50

Table 5 Top 10 cited journals in the field of purinergic receptors in depression

Rank	Journal	Frequency	JCR	IF (2022)
1	Biological Psychiatry	172	Q1	10.6
2	Journal of Neuroscience	165	Q2	5.3
3	Proceedings of the National Academy of Sciences of the United States of America	144	Q1	11.1
4	Molecular Psychiatry	144	Q1	11
5	Neuroscience	131	Q3	3.3
6	Journal of Affective Disorders	129	Q2	6.6
7	Nature	124	Q1	64.8
8	Neuropsychopharmacology	123	Q1	7.6
9	Behavioural Brain Research	119	Q3	2.7
10	Neuropharmacology	115	Q2	4.7

IF: Impact factor; JCR: Journal citation reports.

Table 6 Top 10 frequently cited references about purinergic receptors in depression

Rank	Title of reference	Frequency	Author	Year	Journal
1	Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors	24	Yue N	2017	J Neuroinflamm
2	Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor	23	Iwata M	2016	Biol Psychiat
3	Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders	17	Bhattacharya A	2018	Psychoneuroendocrino
4	Pathological ATPergic Signaling in Major Depression and Bipolar Disorder	16	Illes P	2020	Front Mol Neurosci
5	P2X7 Receptor: A Potential Therapeutic Target for Depression?	16	Deussing JM	2018	Trends Mol Med
6	Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress	15	Kaster MP	2015	P Natl Acad Sci
7	P2X7 Receptor Signaling in Stress and Depression	14	Ribeiro DE	2019	Int J Mol Sci
8	Depression	13	Malhi GS	2018	Lancet
9	Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors	13	Csölle C	2013	Plos One
10	P2X7 receptor: An emerging target in central nervous system diseases	13	Sperlágh B	2014	Trends Pharmacol Sci

Table 7 Top 10 keywords related to migraine and sleep disorders

Rank	Keywords	Frequency
1	Major depressive disorder	36
2	Major depression	36
3	Expression	35
4	Depression	33
5	Brain	33
6	Prefrontal cortex	29
7	P2x (7) receptor	29
8	Stress	26
9	Activation	25
10	Bipolar disorder	22