Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

Table 1 Comparison of baseline data between the two groups

Group	Sex (female/male)	Age (years)	Tumor type, n (%)
			Bladder cancer	Prostate cancer	Kidney cancer	Ureter cancer
Conventional group (n= 55)	20/35	45.67 ± 6.51	28 (50.91)	8 (14.55)	15 (27.27)	4 (7.27)
Joint intervention group (n= 55)	19/36	47.05 ± 5.92	29 (52.73)	9 (16.36)	12 (21.82)	5 (9.09)
χ2/t	0.040	-1.165	0.521
P value	0.842	0.247	0.914

Table 2 Comparison of immune function indexes before and after intervention

Group	CD4+ (%)		CD8+ (%)		CD4+/CD8+
	Before intervention	After intervention	Before intervention	After intervention	Before intervention	After intervention
Conventional group (n= 55)	31.43 ± 1.62	36.10 ± 1.87a	42.06 ± 1.87	40.35 ± 1.72a	0.75 ± 0.05	0.90 ± 0.06a
Joint intervention group (n= 55)	31.16 ± 1.54	41.04 ± 2.30a	42.52 ± 1.60	39.66 ± 1.52a	0.73 ± 0.04	1.03 ± 0.08a
t value	0.919	-12.331	-1.403	2.259	1.772	-11.054
P value	0.360	< 0.001	0.163	0.026	0.079	< 0.001

^aP < 0.0001.

Table 3 Comparison of quality of life questionnaire-core 30 scores before and after intervention

Group	Social function		Emotional function		Cognitive function		Body function		Role function		General health
	Before intervention	After intervention	Before intervention	After intervention	Before intervention	After intervention	Before intervention	After intervention	Before intervention	Before intervention	After intervention	Before intervention
Conventional group (n= 55)	68.22 ± 3.50	73.13 ± 4.47a	65.29 ± 3.50	70.13 ± 3.52a	67.21 ± 3.55	69.11 ± 4.40a	66.36 ± 5.75	68.73 ± 5.99a	60.11 ± 3.50	67.51 ± 4.11a	60.22 ± 4.06	66.25 ± 3.89a
Joint intervention group (n= 55)	68.73 ± 3.58	90.05 ± 5.11a	66.00 ± 3.32	89.78 ± 4.77a	66.56 ± 3.70	89.22 ± 4.30a	65.62 ± 5.66	88.04 ± 5.94a	59.24 ± 3.54	88.64 ± 6.39a	59.49 ± 4.09	87.71 ± 4.70a
t value	-0.754	-18.491	-1.091	-24.603	0.947	-24.247	0.685	-16.975	1.300	-20.625	0.937	-26.068
P value	0.453	< 0.001	0.278	< 0.001	0.346		0.495	< 0.001	0.196	< 0.001	0.351	< 0.001

^aP < 0.0001.

QLQ-C30: Quality of life questionnaire-core 30.

Table 4 Comparison of cancer fatigue scale scores before and after intervention

Group	Body fatigue		Emotional fatigue		Cognitive fatigue		CFS total score
	Before intervention	After intervention	Before intervention	After intervention	Before intervention	After intervention	Before intervention	After intervention
Conventional group (n = 55)	13.91 ± 1.28	12.96 ± 1.23	10.95 ± 1.66	10.22 ± 1.37c	6.96 ± 1.95	6.02 ± 1.55b	31.82 ± 2.67	29.20 ± 2.12c
Joint intervention group (n = 55)	14.09 ± 1.42	11.13 ± 1.07a	10.82 ± 1.76	9.13 ± 1.25b	6.89 ± 1.80	5.29 ± 1.24c	31.80 ± 2.67	25.76 ± 2.19c
t value	-0.706	8.339	0.390	4.365	0.203	2.720	0.036	8.975
P value	0.482	< 0.001	0.698	< 0.001	0.840	0.008	0.971	< 0.001

^aP < 0.05.

^bP < 0.01.

^cP < 0.0001.

CFS: Cancer fatigue scale.

Table 5 Comparison of adverse reactions during the intervention period, n (%)

Group	Urodynia	Hematuria	Dysuria	Frequent and urgent urination	Total incidence (%)
Conventional group (n = 55)	7 (12.73)	5 (9.01)	4 (5.33)	6 (10.91)	22 (40.00)
Joint intervention group (n = 55)	4 (5.33)	2 (3.64)	2 (3.64)	3 (5.45)	11 (20.00)
χ2					5.238
P value					0.022

Table 6 Comparison of nursing satisfaction, n (%)

Group	Very satisfied	Satisfied	Dissatisfied	Satisfaction (%)
Conventional group (n = 55)	22 (40.00)	20 (36.36)	13 (23.64)	42 (76.36)
Joint intervention group (n = 55)	32 (58.18)	19 (34.55)	4 (7.27)	51 (92.73)
χ2				5.636
P value				0.018