Exploring the role of interleukin-6 receptor blockade in epilepsy and associated neuropsychiatric conditions through a mendelian randomization study

Table 1 Incorporate genome-wide association study summary information for the outcomes included in the study

Trait	Data source	Case/control	Ancestry
Epilepsy	Finngen_R10	12891/312803	European
Generalized epilepsy	Finngen_R10	1413/399287	European
Focal epilepsy	Finngen_R10	7526/399290	European
Epilepsy	Ieu-b-8	15212/29677	Mixed
Generalized epilepsy	Ieu-b-9	3769/29677	Mixed
Focal epilepsy	Ieu-b-10	9671/29677	Mixed
Juvenile absence epilepsy	Ieu-b-12	415/29677	Mixed
Juvenile myoclonic epilepsy	Ieu-b-17	1181/29677	Mixed
Childhood absence epilepsy	Ieu-b-13	793/29677	Mixed

Table 2 Inverse variance weighting meta-analysis of mendelian randomization estimates for interleukin-6 receptor blockade in epilepsy

Trait	OR (95%CI)	P value	Case/control
Epilepsy	0.827 (0.685-1.000)	0.050	28103/342480
Generalized epilepsy	0.822 (0.532-1.272)	0.380	5182/428964
Focal epilepsy	0.834 (0.648-1.075)	0.161	17197/428967
Juvenile absence epilepsy	0.987 (0.941-1.036)	0.609	415/29677
Juvenile myoclonic epilepsy	0.967 (0.896-1.044)	0.393	1181/29677
Childhood absence epilepsy	0.984 (0.923-1.049)	0.616	793/29677

OR: Odds ratio; CI: Confidential interval.