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©The Author(s) 2024.
World J Psychiatry. May 19, 2024; 14(5): 695-703
Published online May 19, 2024. doi: 10.5498/wjp.v14.i5.695
Published online May 19, 2024. doi: 10.5498/wjp.v14.i5.695
Table 1 Demographics, clinical symptoms and intelligence quotient in catechol-O-methyltransferase Met-carriers and Val homozygotes
Met-carriers, n = 27 | Val homozygotes, n = 27 | Statistic | u value | P value | |||||
Mean | SD | Mean | SD | ||||||
Age | 34.59 | 7.66 | 33.15 | 7.23 | t = 0.713 | 52 | 0.479 | ||
Educational level | 14.37 | 3.52 | 14.98 | 3.90 | t = -0.604 | 52 | 0.548 | ||
Female/male | 16/11 | 14/13 | χ² = 0.300 | 1 | 0.584 | ||||
Han nationality/non | 24/3 | 25/2 | NA | NA | 1.000 | ||||
Employment/non | 8/19 | 15/12 | χ² = 3.711 | 1 | 0.054 | ||||
Marriage/non | 12/15 | 10/17 | χ² = 0.307 | 1 | 0.580 | ||||
Current smoker/non | 3/24 | 3/24 | NA | NA | 1.000 | ||||
Clozapine user/non | 5/22 | 4/23 | NA | NA | 1.000 | ||||
Chlorpromazine equivalents | 474.96 | 258.23 | 426.50 | 323.60 | t = 0.608 | 52 | 0.546 | ||
Duration of illness | 11.73 | 8.56 | 11.24 | 7.51 | t = 0.223 | 52 | 0.825 | ||
PANSS positive | 9.48 | 3.89 | 8.56 | 2.90 | t = 0.992 | 52 | 0.326 | ||
PANSS negative | 11.15 | 3.31 | 13.59 | 4.93 | t = -2.138 | 52 | 0.037 | ||
PANSS general | 21.48 | 5.15 | 20.59 | 3.86 | t = 0.718 | 52 | 0.476 | ||
PANSS total | 42.11 | 10.02 | 42.74 | 7.89 | t = -0.257 | 52 | 0.799 | ||
WAIS-RC information | 20.67 | 4.66 | 18.41 | 4.80 | t = 1.756 | 52 | 0.085 | ||
WAIS-RC similarities | 18.67 | 2.27 | 18.33 | 2.76 | t = 0.485 | 52 | 0.630 | ||
WAIS-RC picture completion | 11.41 | 3.12 | 10.15 | 2.80 | t = 1.563 | 52 | 0.124 | ||
WAIS-RC block design | 36.19 | 7.19 | 36.44 | 8.44 | t = -0.122 | 52 | 0.904 | ||
WAIS-RC total | 106.61 | 9.75 | 103.00 | 10.54 | t = 1.306 | 52 | 0.197 |
Table 2 Correlations between negative symptoms and intelligence quotient, demographics, clinical characteristics in total participants (n = 54)
Information | Similarities | Picture completion | Block design | WAIS-RC total | Education | Age | CE | Duration of illness | ||
PANSS negative | r value | -0.405 | -0.475 | -0.332 | -0.385 | -0.527 | -0.384 | 0.019 | -0.243 | -0.119 |
P value | 0.002 | < 0.001 | 0.014 | 0.004 | < 0.001 | 0.004 | 0.894 | 0.076 | 0.391 |
Table 3 The effects of gender, employment and marriage on negative symptoms
Gender/employment/marriage | n | Mean | SD | t value | u value | P value | |
PANSS negative | Male | 24 | 13.63 | 4.79 | 1.949 | 52 | 0.057 |
Female | 30 | 11.37 | 3.73 | ||||
Employed | 23 | 11.91 | 3.85 | -0.663 | 52 | 0.510 | |
Non | 31 | 12.71 | 4.71 | ||||
Married | 32 | 12.09 | 4.71 | -0.561 | 52 | 0.577 | |
Non | 22 | 12.77 | 3.80 |
Table 4 Correlations of negative symptoms with information, similarities in catechol-O-methyltransferase met-carriers and Val homozygotes
Information | Similarities | |||
PANSS negative | Met-carriers (n = 27) | r value | -0.099 | -0.223 |
P value | 0.624 | 0.263 | ||
Val/Val (n = 27) | r value | -0.544 | -0.62 | |
P value | 0.003 | 0.001 | ||
Correlation coefficient comparison | Z value | 1.768 | 1.726 | |
P value | 0.038 | 0.042 | ||
Interaction test1 | β value | -0.282 | -0.250 | |
95%CI | -0.552 to -0.011 | -0.495 to -0.004 | ||
P value | 0.042 | 0.046 |
- Citation: Hou WP, Qin XQ, Hou WW, Han YY, Bo QJ, Dong F, Zhou FC, Li XB, Wang CY. Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia. World J Psychiatry 2024; 14(5): 695-703
- URL: https://www.wjgnet.com/2220-3206/full/v14/i5/695.htm
- DOI: https://dx.doi.org/10.5498/wjp.v14.i5.695