Review
Copyright ©The Author(s) 2024.
World J Psychiatry. May 19, 2024; 14(5): 607-623
Published online May 19, 2024. doi: 10.5498/wjp.v14.i5.607
Table 1 List of additional herbal treatments that exhibit antidepressant-like effects
Ref.
Herbs
Herbal constituents
Administration dosage
Models
Mechanism of action
Terpenes and phenylpropanoids
Alotaibi et al[78], 2022Illicium dunnianum Tutch.Macranthol10, 20, 40 mg/kg, p.o.CUMS miceBDNF
Dai et al[56], 2022Magnolia officinalis Rehd et Wils.Honokiol2, 4, 8 mg/kg, i.g.CUMS miceThe HPA axis/BDNF
Zhao et al[40], 2023Psoralea corylifolia Linn.Bakuchiol analogs0.03-333 μMTr-CHO cellsMonoamine
Zeng et al[79], 2021Hemsleya amabilis DielsCucurbitacin IIa2.5, 5 mg/kg, i.pCUMS miceBDNF
Chen et al[80], 2023Crocus sativus L.Crocin12.5, 25, 50 mg/kg, i.p.RatsBDNF
Adam et al[116], 2023Perilla frutescens (L.) Britt.Rosmarinic acid5 and 10 mg/kg, i.p.CUS RatsBDNF
Carbohydrates
Bildziukevich et al[117], 2023Acanthopanax Miq.Chiisanoside2.5 and 5 mg/kg, i.pLPS-induced miceBDNF
Salehi et al[118], 2023Aconitum carmichaelii DebeauxFuzi polysaccharide 150, 100 mg/kg, i.p.MiceBDNF
Li et al[119], 2022Morinda officinalis HowOligosaccharide5, 10, 125, 500 mMCORT-induced PC12The HPA axis
Alkaloids
Salehi et al[118], 2023Aconitum carmichaelii DebeauxTotal alkaloid10, 30 mg/kg, i.g.Ovariectomized miceBDNF
Ali et al[120], 2023Stephania tetrandra S. MooreTetrandrine10, 20, 40 mg/kg, i.g.CUMS RatsMonoamine/BDNF
Shayganfard[121], 2023Berberis aristata Linn.Berberine Chloride5, 10, 20 mg/kg, i.pMale albino miceMonoamine
Sun et al[122], 2023Scutellaria baicalensis GeorgiBaicalein1, 2, 4 mg/kg, i.p.CUMS miceBDNF
Flavonoids
Yu et al[123], 2022Pueraria lobate (Willd.) OhwiPuerarin60 and 120 mg/kg, i.gCUS RatsMonoamine/the HPA axis
Yu et al[123], 2022Pueraria lobate (Willd.) OhwiPueraria isoflavone10 and 100 mg/kgOvariectomy miceBDNF
Wang et al[124], 2021Apocynum venetum L.Flavonoid Extract25, 50, 100 mg/mlCORT-induced PC12BDNF
Mu and Ma[125], 2022Gastrodia elata Bl.Gastrodin50, 100, 200 mg/kg, i.p.CUS RatsBDNF
Glycosides
Nagakura[126], 2022Gentiana lutea L.Gentiopicroside50, 100, 200 mg/kg, i.g.Reserpine-induced miceGlutamate transmission
Yin et al[127], 2023Paeonia lactiflora Pall.Total glycosides160 mg/kg, p.o.CORT-induced ratsBDNF
Sánchez et al[128], 2023Rhodiola rosea L.Salidroside20, 40 mg/kg, p.oBehavioral despair ratsThe HPA axis/BDNF
Saponins
Liu et al[129], 2023Anemarrhena asphodeloides BungeYY-2320 mg/kg, i.g.CMS miceGlutamate transmission
Zhuang et al[58], 2023Bupleurum chinense DC.Saikosaponin D0.75 and 1.50 mg/kg, i.g.CUMS ratsThe HPA axis
Yoon et al[130], 2023Panax ginseng C.A. Mey.Ginsenoside Rg140 mg/kg, i.p.CUMS ratsBDNF
Tian et al[131], 2023Anemarrhena asphodeloides BungeSarsasapogenin12.5, 25, 50 mg/kg, p.o.CUMS miceMonoamine