Des-Arg(9) bradykinin as a causal metabolite for autism spectrum disorder

Table 3 Heterogeneity and pleiotropy tests of the 8 metabolites

Metabolite	Heterogeneity, MR Egger P value	Heterogeneity, IVW P value	Pleiotropy, P value
Biliverdin	0.392	0.415	0.496
1,5-anhydroglucitol	0.482	0.034	0.067
Butyrylcarnitine	0.174	0.007	0.016
10-Undecenoate (11:1n1)	0.844	0.689	0.556
Oxidized bilirubin	0.271	0.385	0.586
Isovalerylcarnitine	0.030	0.058	0.744
Des-Arg(9) bradykinin	0.663	0.906	0.949
Alpha-glutamyltyrosine	0.785	0.923	0.817

MR: Mendelian randomization; IVW: Inverse variant weight.