Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy

doi:10.5498/wjp.v11.i12.1177

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World Journal of Psychiatry

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2220-3206

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World J Psychiatr. Dec 19, 2021; 11(12): 1177-1190
Published online Dec 19, 2021. doi: 10.5498/wjp.v11.i12.1177

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Figure 2 Major pathways of polyamines biosynthesis and interconversion (from Gross and Turecki[71]; scheme reproduced with permission of Bentham; modified). ADC: Arginine decarboxylase; AGMAT: Agmatinase; AMD: S-adenosylmethionine decarboxylase; ARG: Arginase; AZIN: Ornithine decarboxylase antizyme inhibitor; dcSAM: Decarboxylated S-adenosylmethionine; MTA: 5’-methylthioadenosine; OAT: Ornithine aminotransferase; OAZ: Ornithine decarboxylase antizyme; ODC: Ornithine decarboxylase; PAO: Polyamine oxidase; SAM: S-adenosylmethionine; SAT1: Spermidine/SpermineN1 acetyltransferase; SMS: Spermine synthase; SMOX: Spermine oxidase; SRM: Spermidine synthase.

Citation: Bernstein HG, Keilhoff G, Laube G, Dobrowolny H, Steiner J. Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy. World J Psychiatr 2021; 11(12): 1177-1190
URL: https://www.wjgnet.com/2220-3206/full/v11/i12/1177.htm
DOI: https://dx.doi.org/10.5498/wjp.v11.i12.1177