Regulation of the cell fate by DNA damage and hypoxia

Figure 1 p300/CBP associated factor mediates p53 and hypoxia inducible factor-1α transcription target selectivity in a manner dependent on the type of stress. In DNA damage conditions the p300/CBP associated factor (PCAF) is recruited to the promoters of pro-apoptotic gene targets thus inducing p53 mediated cell death, whereas in conditions of low oxygen availability PCAF mediates p53 and hypoxia inducible factor 1α (HIF-1α) post-translational modifications that selectively target both transcription factors to a subset of their transcription target genes with pro-survival activity thereby inducing cell proliferation.

Figure 2 p300/CBP associated factor determines cellular energy metabolism pathways under diverse types of stress. Differential post-translational modifications of p53 and hypoxia inducible factor 1α (HIF-1α) mediated by p300/CBP associated factor (PCAF), distinctly modulate cellular energy metabolism pathways by activating or repressing the expression of their target genes Tp53 induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2). PFK: Phosphofructokinase.