Epigenetics in the etiology and management of infertility

Figure 1  Flow chart of article selection.

Figure 2  Epigenetic mechanisms.

Figure 3 DNA methylation (arrow pointing right) and de-methylation (arrow pointing left) via DNA methyltransferase and ten-eleven translocation, respectively. DNMTs: DNA methyltransferase; TETs: Ten-eleven translocation.

Figure 4 DNA methylation and de-methylation processes, showing the roles of each modulating enzyme; DNMT1, DNMT3A, and DNMT3B stand for DNA methyltransferases 1, 3A, and 3B, respectively; TET2 is short for ten-eleven translocation. DNMTs: DNA methyltransferase; TETs: Ten-eleven translocation.

Figure 5  Histone post-translational modification processes, showing mechanisms.