DNA methylation in liver diseases

Table 1 A selection of methylated genes in hepatocellular carcinoma

Gene	Location	Function	Methylation frequency	Ref.
GSTP1	11q13.2	Detoxification	41%-58%	[85-87]
SOCS1	16p13.13	Cytokine inhibitor	60%	[88]
RASSF1A	3p21.3	Apoptosis	54%-95%	[89,90]
E-Cadherin	16q22.1	Cell adhesion	33%-67%	[91,92]
APC	5q22.2	Signal transduction	46%	[93]
p16	9q21.3	CDK inhibitor	17%-83%	[94,95]
SFRP1	8p11.21	Signal transduction	59.50%	[96]
WIF-1	12q14.3	Signal transduction	61.90%	[97]
MGMT	10q26	DNA repair	22%-39%	[98,99]
TFPI2	7q21.3	Protease inhibitor	46.50%	[100]