ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells

Table 1 Among these selected genes, the top ten genes up-regulated or down-regulated by nicotine treatment in human coronary artery endothelial cells were detected by IPA

Symbol	Gene name	Expression change
KCNQ1	Potassium voltage-gated channel, KQT-like subfamily, member 1	6.09
MYCN	V-myc myelocytomatosis viral related oncogene, neuroblastoma derived	5.761
RRAGD	Ras-related GTP binding D	4.56
TNNI1	Troponin I type 1	3.933
FCN1	Ficolin 1 (collagen/fibrinogen domain containing)	3.866
C1orf204	Chromosome 1 open reading frame 204	3.792
PCDHGC4	Protocadherin gamma subfamily C, 4	3.657
C14orf165	Chromosome 14 open reading frame 165	3.461
TLR2	Toll-like receptor 2	3.443
RCAN2	Regulator of calcineurin 2	3.431
LAIR1	Leukocyte-associated immunoglobulin-like receptor 1	-5.014
SIX3	SIX homeobox 3	-4.926
MYO1A	Myosin IA	-4.824
PRTN3	Proteinase 3	-4.173
MRGPRE	MAS-related GPR, member E	-3.914
EGR2	Early growth response 2	-3.766
CASQ1	Calsequestrin 1	-3.587
CLEC12B	C-type lectin domain family 12, member B	-3.338
ALPI	Alkaline phosphatase, intestinal	-3.033
SLC7A14	Solute carrier family 7, member 14	-2.941

Table 2 In the nicotine-treated human coronary artery endothelial cells, IPA generated the networks

Associated network functions	Score
Tissue development, cardiovascular system development and function, cell-to-cell signaling and interaction	40
Cellular movement, immune cell trafficking, inflammatory response	32
Cellular growth and proliferation, cellular movement, cellular development	30
Cellular growth and proliferation, carbohydrate metabolism, molecular transport	27
Antimicrobial response, humoral immune response, cell-to-cell signaling and interaction	24