Evidence, hypotheses and significance of MAP kinase TNNI3K interacting with its partners

Table 1 The interaction partners with TNNI3K

Putative partners	Effects of the interaction on cardiac system	Ref.
Cardiac troponin I	To suppress the phosphorylation of cTnI and increase cardiac functions	Zhao et al[1], 2003
		Lai et al[4], 2008
Antioxidant protein 1	To suppress TNNI3K activity through binding to the sides of ankyrin motif or protein kinase domain of TNNI3K	Feng et al[8], 2007
Cardiac α-actin(in)	To increase expression of α-actinin	Zhao et al[1], 2003
		Lai et al[4], 2008
Endothelin-1	To increase endothelin-1-induced cardiomyocytes hypertrophy	Wang et al[5], 2011
Calsequestrin	To impair systolic contract function and reduce animal survival	Wheeler et al[6], 2009
MADS-box factor myocyte enhancer factor-2 (Mef2c)	To down-regulate TNNI3K transcription level	Wang et al[7], 2008
Cardiac myosin binding protein C	Unconfirmed	Zhao et al[1], 2003
Adult skeletal muscle α-actin	Unconfirmed	Zhao et al[1], 2003
Arylhydrocarbon receptor-interacting protein	Unconfirmed	Zhao et al[1], 2003
Fatty acid binding protein 3 of heart	Unconfirmed	Zhao et al[1], 2003
Trifunctional enzyme -subunit, mitochondrial precursor	Unconfirmed	Zhao et al[1], 2003