Oxidative stress-mediated effects of angiotensin II in the cardiovascular system

doi:10.5494/wjh.v2.i4.34

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Aug 23, 2012 (publication date) through Dec 4, 2024

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World Journal of Hypertension

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2220-3168

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hypertens. Aug 23, 2012; 2(4): 34-44
Published online Aug 23, 2012. doi: 10.5494/wjh.v2.i4.34

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Figure 1 A schematic diagram illustrating the involvement of ROS signaling pathways in numeral Ang II-induced cardiovascular diseases. See main text for details. Ang II: Angiotensin II; AT₁R: Angiotensin II type 1 receptor; AT₂R: Angiotensin II type 2 receptor; ROS: Reactive Oxygen Species; CaMKII: calcium/calmodulin-dependent protein kinase II; I_Na: Sodium current; I_Ca,L: L-type calcium current; NCX: Sodium-Calcium current; SR: Sarcoplasmic reticulum; RyR: Ryanodine receptor; SERCA: SR Ca²⁺ ATPase; EAD: Early afterdepolarization; DAD: Delayed afterdepolarization.

Citation: Wen H, Gwathmey JK, Xie LH. Oxidative stress-mediated effects of angiotensin II in the cardiovascular system. World J Hypertens 2012; 2(4): 34-44
URL: https://www.wjgnet.com/2220-3168/full/v2/i4/34.htm
DOI: https://dx.doi.org/10.5494/wjh.v2.i4.34