Anti-hypertensive effect of enriched white melon seed protein concentrate biscuit on sodium fluoride exposed rats

Table 1 Effects of 10% and 20% WSP biscuit diets on the ventricular thickness of control and treated Wistar rats, mean ± SEM

Group	Left ventricular thickness (µm)
A	1225.00 ± 22.30
B	1235.00 ± 55.30
C	1243.00 ± 45.08
D	1799.00 ± 50.30b
E	1300.00 ± 40.02a,c
F	1230.00 ± 23.09c
G	1224.00 ± 24.09c

^aP < 0.05.

^bP < 0.0001 vs the normal control group.

^cP < 0.0001 vs sodium fluoride exposed only group.

Group A: Normal control group; Group B: Received 10% white melon seed protein (WSP) biscuit meal only; Group C: Received 20% WSP biscuit meal only; Group D: Orally received 300 mg/L sodium fluoride (NaF) in drinking water; Group E: Received 300 mg/L NaF + Lisinopril (10 mg/kg bwt); Group F: Received 300 mg/L NaF + 10% WSP biscuit meal; Group G: Received 300 mg/L NaF and 20% WSP biscuit meal.

Table 2 Showing the effects of 10% and 20% white melon seed protein biscuit diets on collagen deposit in control and treated Wistar rats, mean ± SEM

Group	Masson’s trichrome staining intensity/µm2
A	10.03 ± 0.02
B	10.02 ± 0.10
C	10.00 ± 0.08
D	18.09 ± 0.30a
E	10.5 ± 0.07b
F	10.10 ± 0.90b
G	10.04 ± 0.09b

^aP < 0.0001 vs the normal control group.

^bP < 0.0001 vs sodium fluoride exposed only group.

Group A: Normal control group; Group B: Received 10% white melon seed protein (WSP) biscuit meal only; Group C: Received 20% WSP biscuit meal only; Group D: Orally received 300 mg/L sodium fluoride (NaF) in drinking water; Group E: Received 300 mg/L NaF + Lisinopril (10 mg/kg bwt); Group F: Received 300 mg/L NaF + 10% WSP biscuit meal; Group G: Received 300 mg/L NaF and 20% WSP biscuit meal.