Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate

doi:10.5493/wjem.v10.i1.1

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 1

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5314)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

220

WORD

203

HTML

2791

Figures (1-1)

360

Tables (1-3)

303

Sum=3877

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

654

Download

783

Sum=1437

Jan 8, 2020 (publication date) through Nov 4, 2024

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Experimental Medicine

ISSN

2220-315x

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Exp Med. Jan 8, 2020; 10(1): 1-9
Published online Jan 8, 2020. doi: 10.5493/wjem.v10.i1.1

Table 1 Median, minimum and maximum values of linear value found between the apex of the greater trochanter until to the lower intercondylar midlle face

Day	Linear Size of Femur (cm)		P value
Day	Control	Alendronate	P value
3	5.93 (5.67 – 6.04)	6.85 (5.99 – 7.21)	P = 0.062
12	12.72 (11.67-13.52)	8.84 (8.43 – 9.08)	P = 0.027

For each same time period values P > 0.05 are statistically similar.

Table 2 Median, minimum and maximum values of area in mm2 of each chondroid zone

Cartilage zone	Area accounted (mm²)
	3^rd day			12^th day
	Control	Alendronate	P value	Control	Alendronate	P value
Reserve	6.12 (5.52-6.51)	5.63 (5.07-5.71)	P = 0.061	3.33 (3.22-3.51)	2.26 (2.11-2.29)	P = 0.056
Proliferative	4.02 (3.82-4.44)	4.12 (3.98-4.58)	P = 0.071	3.38 (3.35-3.43)	3.11 (3.05-3.26)	P = 0.061
Maturation	0.4 (0.32-0.46)	0.36 (0.29-0.40)	P = 0.073	0.27 (0.16-0.29)	0.04 (0.01-0.06)	P = 0.002
Hipertrophic	4.12 (3.66-4.31)	7.59 (7.31-7.77)	P = 0.032	4.02 (3.96-4.26)	2.17 (2.11-2.32)	P < 0.0001

For each same time period values P < 0.05 were considered statistically different.

Table 3 Percentage in median, minimum and maximum for transforming growth factor-β1 and bone morphogenetic protein-2 values in cells for chondroid zone

Chondroid layer	Day	TGF-b1		P value	BMP-2		P value
Chondroid layer	Day	Control	Alendronate	P value	Control	Alendronate	P value
Reserve	3	-	-	-	-	12 (10-14)	P < 0.001
Reserve	12	-	-	-	-	34 (30-36)	P < 0.001
Proliferative	3	23.01 (19-26)	16.27 (14-19)	P = 0.047	-	72.21 (70-75)	P < 0.001
Proliferative	12	19.12 (17-23)	2.33 (0-3)	P < 0.001	-	67.43 (66-69)	P < 0.001
Maturation	3	89.64 (85-93)	93.07 (91-94)	P = 0.673	-	88.61 (86-81)	P < 0.001
Maturation	12	83 (80-84)	1.06 (0-1)	P < 0.001	13 (12-15)	94.05 (92-98)	P < 0.001
Hipertrophic	3	96.35 (94-99)	97.66 (95-98)	P = 0.772	2 (2-3)	82.17 (80-85)	P < 0.001
Hipertrophic	12	93.52 (92-95)	92.31 (90-93)	P = 0.694	42 (41-44)	93.00 (90-95)	P = 0.027

For each same time period values P < 0.05 were considered statistically different.

Citation: Vieira JS, Cunha EJ, de Souza JF, Chaves LHK, de Souza JL, Giovanini AF. Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate. World J Exp Med 2020; 10(1): 1-9
URL: https://www.wjgnet.com/2220-315x/full/v10/i1/1.htm
DOI: https://dx.doi.org/10.5493/wjem.v10.i1.1