miRNA dysregulation in Duchenne muscular dystrophy comorbidities

Figure 1 Schematic representation of the disease-onset stages for the child exhibiting DMD, epilepsy, and ASD. ASD: Autism spectrum disorder; DMD: Duchenne muscular dystrophy.

Figure 2  Pedigree chart for three generations of the proband with Duchenne muscular dystrophy, autism spectrum disorder, and epilepsy.

Figure 3 The differential expression of miRNA represented as fold change across the 3 samples: Control, Duchenne muscular dystrophy (DMD+), and DMD++. A: miR-146a-3p; B: miR-146a-5p; C: miR-132-3p; D: miR-132-5p; E: miR-199a-5p. Significance is presented as ^aP ≤ 0.01 and ^bP ≤ 0.001. Data are presented as the mean ± SEM. DMD: Duchenne muscular dystrophy.

Figure 4 Variations in the lower limb of patients with dystrophy. A: Duchenne muscular dystrophy (DMD+); B: DMD++.