Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test, proof of acini–islet–acinar interactions

Figure 1 Schematic diagram showing the placement of the catheter, ensuring infusions exclusively to the pancreas and partially to the duodenum. BSA: Bovine serum albumin.

Figure 2 Glucose and insulin levels after the intravenous glucose tolerance test in pigs 1 and 4 during infusion of amylase to the intrapancreatic arterial circulation. A: Blood glucose levels; B: Plasma insulin levels. Data are expressed as individual values, data on area under the curve are expressed as mean ± SD. AUC: Area under the curve.

Figure 3 Glucose and insulin levels after the intravenous glucose tolerance test in pigs 5 and 6 during infusion of amylase to the intrapancreatic arterial circulation. A: Blood glucose levels; B: Plasma insulin levels. Data are expressed as individual values, data on area under the curve are expressed as mean ± SD. AUC: Area under the curve.

Figure 4 Glucose and insulin levels after the intravenous glucose tolerance test in pigs 2 and 3 during infusion of amylase to the intrapancreatic arterial circulation. A: Blood glucose levels; B: Plasma insulin levels. Data are expressed as individual values, data on area under the curve are expressed as mean ± SD. AUC: Area under the curve; BSA: Bovine serum albumin.