Safety and efficacy of autologous bone marrow aspirate concentrate injection for idiopathic male infertility: A comparative study

Table 1 Characteristics of patients included in the study, n (%)

Patient characteristics	Group 1 (bone marrow aspirate concentrate)	Group 2 (pharmacotherapy)	Group 3 (lifestyle modifications)	P value
Age (years)	42.2 ± 3.3	40 ± 4.1	39 ± 4.9	0.543
Sperm count	4.75 ± 6.8	7.18 ± 5.3	11.85 ± 4.7	0.064
Sperm motility grade
Slow progressive motility	0	1 (10)	2 (20)	0.043
Non-progressive motility	3 (30)	8 (80)	5 (50)
Immotile	4 (40)	1 (10)	3 (30)
Azoospermia	4 (40)	0	0

Table 2 Evaluation of sperm count among the three groups analyzed

Patient number	Sperm count (in millions)
	Group 1 (bone marrow aspirate concentrate)			Group 2 (pharmacotherapy)			Group 3 (lifestyle modifications)
	Baseline	6 months	∆	Baseline	6 months	∆	Baseline	6 months	∆
1	3.3	88	84.7	14	55	41	8	8	0
2	2	22	20	12.5	22	9.5	15	19	4
3	10	24	14	0.5	1	0.5	5	2	-3
4	0	2	2	0.8	1	0.2	16	20	4
5	0	0.8	0.8	7.5	10	2.5	9	10	1
6	0	1	1	2	6	4	18	25	7
7	18	30	12	4	6	2	12	15	3
8	0	N/A	N/A	12	20	8	5	N/A	N/A
9	4	N/A	N/A	5.5	12	6.5	8	N/A	N/A
10	5	N/A	N/A	13	22	9	4	N/A	N/A
Mean	4.7	23.9	19.2	7.1	15.5	3.5	11.8	14.1	2.2

N/A: Not available.

Table 3 Evaluation of sperm motility grade among the three groups analyzed

Patient number	Sperm motility grade1
	Group 1 (bone marrow aspirate concentrate)			Group 2 (pharmacotherapy)			Group 3 (lifestyle modifications)
	Baseline	6 months	∆	Baseline	6 months	∆	Baseline	6 months	∆
1	B	A	+1	B	B	-	B	B	-
2	B	A	+1	A	A	-	A	A	-
3	C	B	+1	C	C	-	B	B	-
4	-	B	+3	B	B	-	B	B	-
5	-	B	+3	B	B	-	C	C	-
6	-	C	+1	B	B	-	B	B	-
7	B	A	+1	C	C	-	A	A	-
8	C	N/A	N/A	B	B	-	C	N/A	N/A
9	C	N/A	N/A	B	B	-	B	N/A	N/A
10	C	N/A	N/A	B	B	-	D	N/A	N/A

¹Normal motility.

A: Slow progressive motility; B: Non progressive motility; C: Immotile; N/A: Not available.