Anti-epileptic medication induced disturbed calcium-vitamin D metabolism: A behavioral analysis using association rule mining technique

Table 1 Demographic characteristics

Parameters	Age (years)	Duration of seizure (years)	Age at onset	Frequency of seizure (months)	last seizure (months)	Albumin (gm/dL)	PTH (pg/mL)	TSH (mU/L)	Vitamin D (ng/mL)	S calcium (mg/dL)	S phosphorous (mg/dL)	Class
Count	150	150	150	150	150	150	150	150	150	150	150	150
mean	24.1	5.21	19.3	2.45	4.41	4.43	47.8	2.82	15.1	1.02	4.59	1
Std	9.67	3.74	8.26	4.61	6.59	0.25	28.3	1.88	9.75	0.12	0.74	0.81
Min	12	1.2	4	0.11	0.13	4	1.52	0.9	3	0.81	2.4	0
25%	17	3.6	13.2	0.17	0.25	4.2	17.8	1.48	9.41	0.94	4.10	0
50%	22	4	18	0.2	2	4.4	57.3	2.4	13.3	1.01	4.7	1
75%	28.7	5	23	0.33	6	4.7	70.7	3.6	19.1	1.08	4.97	2
Max	60	36	50	12	36	4.9	131.	19.0	70	1.5	6.71	2

PTH: Parathyroid hormone, TSH: Thyroid stimulating hormone; S phosphorous: Serum phosphorus; Std: Standard; Min: Minimum; Max: Maximum.

Table 2 The 150 examples of major epilepsy neurology rules in the overall population. Polytherapy is the goal value for epilepsy neurology (50 instances)

Rules	Antecedents	Consequents	Support	Confidence	Lift
R1	PTH > 62, last seizure (months) > 0.25, phosphorous > 4.2	Poly	0.33	0.93	2.8
R2	PTH > 62, last seizure (months) > 0.25, Vitamin D ≤ 17.19	Poly	0.33	0.93	2.79
R3	PTH > 62, S_phosphorous > 4.32, last seizure (months) > 0.25	Poly	0.33	0.93	2.79
R4	Duration of seizure (years) > 3.6, PTH > 61, last seizure (months) > 0.25	Poly	0.33	0.91	2.74
R5	Duration of seizure (years) > 3.6, phosphorous > 4.32, PTH > 58	Poly	0.33	0.89	2.68
R6	PTH > 62, last seizure (months) > 0.25	Poly	0.33	0.86	2.59
R7	Duration of seizure (years) > 3.6, PTH > 61, phosphorous > 4.2	Poly	0.33	0.85	2.56
R8	PTH > 62, phosphorous > 4.32, PTH ≤ 85	Poly	0.33	0.82	2.45
R9	Duration of seizure (years) > 3.6, PTH > 61	Poly	0.33	0.8	2.39
R10	PTH > 62, phosphorous > 4.32	Poly	0.33	0.78	2.35
R11	Duration of seizure (years) > 3.6, phosphorous > 4.32, last seizure (months) > 0.25	Poly	0.33	0.76	2.29
R12	PTH > 62	Poly	0.33	0.68	2.03
R13	Duration of seizure (years) > 3.6, S phosphorous > 4.32	Poly	0.33	0.65	1.94
R14	Duration of seizure (years) > 3.6	Poly	0.33	0.48	1.44

PTH: Parathyroid hormone; Poly: Polytherapy; S phosphorous: Serum phosphorus.

Table 3 The significant rules of epilepsy neurology in the total population: 150 instances. Monotherapy is the goal value for epilepsy neurology (50 instances)

Rules	Antecedents	Consequents	Support	Confidence	Lift
R1	PTH ≤ 27.25, last seizure (months) > 0.25, duration of seizure(years) ≤ 10	Mono	0.33	1	3
R2	PTH ≤ 27.25, last seizure (months) > 0.25	Mono	0.33	0.98	2.93
R3	PTH ≤ 27.25, duration of seizure(years) ≤ 10	Mono	0.33	0.82	2.45
R4	PTH ≤ 27.25	Mono	0.33	0.8	2.4
R5	FT3 13.1.20 > 2.14, last seizure (months) > 0.5, age at onset > 9	Mono	0.33	0.6	1.79
R6	FT3 13.1.20 > 2.14, last seizure (months) > 0.5, FT4 13.1.20 > 0.72	Mono	0.33	0.58	1.74
R7	FT3 13.1.20 > 2.14, age at onset > 9, FT4 13.1.20 > 0.72	Mono	0.33	0.57	1.71
R8	FT3 13.1.20 > 2.14, last seizure (months) > 0.5	Mono	0.33	0.55	1.64
R9	FT3 13.1.20 > 2.14, age at onset > 9, age (in years) ≤ 53	Mono	0.33	0.54	1.62
R10	FT3 13.1.20 > 2.14, age at onset > 9	Mono	0.33	0.53	1.6
R11	FT3 13.1.20 > 2.14	Mono	0.33	0.49	1.46

PTH: Parathyroid hormone; Mono: Monotherapy; FT3: Free T3; FT4: Free T4.

Table 4 The 150 cases of major epilepsy neurology rules in the overall population. Dual therapy is the goal value for epilepsy neurology (50 instances)

Rules	Antecedents	Consequents	Support	Confidence	Lift
R1	{Last Seizure (months) ≤ 0.33}	Dual	0.33	1	3
R2	{FT3 13.1.20 ≤ 1.84, PTH > 14.29, phosphorous ≤ 5.81}	Dual	0.33	0.91	3
R3	{FT3 13.1.20 ≤ 1.84, PTH > 14.29, frequency of seizure (months) > 0.11}	Dual	0.33	0.89	3
R4	{FT3 13.1.20 ≤ 1.84, vitamin D > 6.34, PTH > 13.26}	Dual	0.33	0.89	3
R5	{FT3 13.1.20 ≤ 1.84, PTH > 14.29}	Dual	0.33	0.87	3
R6	{FT3 13.1.20 ≤ 1.84, vitamin D > 6.34, S phosphorous ≤ 5.81}	Dual	0.33	0.85	3
R7	{FT3 13.1.20 ≤ 1.84, vitamin D > 6.34}	Dual	0.33	0.82	3
R8	{FT3 13.1.20 ≤ 1.84}	Dual	0.33	0.77	3

Dual: Dual therapy; PTH: Parathyroid hormone; FT3: Free T3; S phosphorous: Serum phosphorus.