Association of cannabis use disorder with atrial fibrillation in young men without concomitant tobacco use: Insights from nationwide propensity matched analysis

Table 1 Baseline characteristics of young men hospitalizations without concomitant tobacco use disorder with vs without cannabis use disorder, 2019, n (%)

Variable		Cannabis use disorder		P value
		No (n = 108495)	Yes (n = 108495)
Age (years) at admission	Median (IQR)	30	30	< 0.001
Race				< 0.001
	White	53525 (49.30)	53365 (49.20)
	Black	27670 (25.50)	27830 (25.70)
	Hispanic	19480 (18.00)	19465 (17.90)
	Asian or Pacific Islander	1605 (1.50)	1840 (1.70)
	Native American	1200 (1.10)	1190 (1.10)
Median household income national quartile for patient ZIP code				0.100
	0-25th	38785 (35.70)	38400 (35.40)
	26-50th	26595 (24.50)	26730 (24.60)
	51-75th	24615 (22.70)	24500 (22.60)
	76-100th	18500 (17.10)	18865 (17.40)
Primary payer				< 0.001
	Medicare	10325 (9.50)	9365 (8.70)
	Medicaid	43715 (40.40)	43730 (40.40)
	Private insurance	32395 (29.90)	31465 (29.10)
	Self-pay	14675 (13.60)	17045 (15.70)
	No charges	1385 (1.30)	1455 (1.30)
	Other	5750 (5.30)	5180 (4.80)
Hypertension, complicated		6835 (6.30)	5700 (5.30)	< 0.001
Hypertension, uncomplicated		16735 (15.40)	16335 (15.10)	0.010
Hyperlipidemia		7445 (6.90)	6900 (6.40)	< 0.001
Obesity		11780 (10.90)	9920 (9.10)	< 0.001
Peripheral vascular disease		1510 (1.40)	970 (0.90)	< 0.001
Chronic pulmonary disease		10235 (9.40)	10590 (9.80)	0.010
Alcohol abuse		18325 (16.90)	16770 (15.50)	< 0.001
Drug abuse		55370 (51.00)	55380 (51.00)	0.960
Diabetes with chronic complications		7375 (6.80)	6890 (6.40)	< 0.001
Diabetes without chronic complications		3735 (3.40)	2950 (2.70)	< 0.001
Prior myocardial infarction		1170 (1.10)	1070 (1.00)	0.030
Prior transient ischemic attack/stroke		1570 (1.40)	1165 (1.10)	< 0.001
Depression		12800 (11.80)	13210 (12.20)	0.007
Prior VTE		3475 (3.20)	1910 (1.80)	< 0.001
Cancer		3030 (2.80)	1745 (1.60)	< 0.001

P < 0.05 indicates statistical significance. IQR: Interquartile range, VTE: Venous thromboembolism.

Table 2 Odds of atrial fibrillation related admissions in young men without concomitant tobacco use disorder with vs without cannabis use disorder by logistic regression

Item	OR	95%CI lower limit	95%CI upper limit	P value
Unadjusted	1.19	0.85	1.66	0.313
Adjusted for age, race, income quartile, hospital location/teaching status, and regions	1.19	0.85	1.67	0.300
Adjusted for all baseline patient level and hospital level sociodemographic characteristics and pre-existing comorbidities	1.27	0.91	1.78	0.158

P < 0.05 indicates statistical significance. Multivariable regression models were adjusted for age at admission, race, median household income national quartile for patient ZIP Code, location/teaching status of the hospital, region of the hospital, alcohol abuse, other drug abuse, depression, complicated hypertension, diabetes with chronic complications, hyperlipidemia, obesity, peripheral vascular disease, prior myocardial infarction, chronic pulmonary disease, prior venous thromboembolism, and cancer. 95%CI: 95% confidence interval; OR: Odds ratio.