Red cell distribution width: A predictor of the severity of hypertriglyceridemia-induced acute pancreatitis

Table 1 Demographic and clinical characteristics of the patients, N (%)

Variable	Non-POF (n = 68)	POF (n = 34)	Univariate P	Multivariate P
Age (yr)	40 ± 8	40 ± 9	0.967
Sex (M/F)	56/12	29/5	0.785
Hypertension	16 (24)	7 (21)	0.876
Diabetes	33 (49)	22 (65)	0.144
Fatty liver disease	39 (57)	16 (47)	0.679
Alcohol	28 (41)	15 (44)	0.833
Smoking	45 (66)	21 (62)	0.667
WBC (x109/L)	12.4 (10.9, 15.9)	14.9 (13.2, 17.1)	0.009	0.172
MPV (fL)	10.42 ± 1.76	11.54 ± 2.06	0.012	0.085
RDW (%)	12.5 (12.0, 13.0)	14.4 (13.4, 14.9)	< 0.001	0.002
Amylase (U/L)	124 (66, 258)	239 (83, 917)	0.036	0.383
Calcium (mmol/L)	2.35 (2.25, 2.42)	2.29 (2.10, 2.95)	0.064
Triglyceride (mmol/L)	16.42 (11.58, 20.31)	19.57 (15.23, 24.70)	0.010	0.101
ALT (U/L)	36.0 (25.0, 47.4)	35.2 (20.8, 46.6)	0.412
AST (U/L)	25.9 (19.1, 31.7)	25.4 (17.9, 33.6)	0.879
Albumin (g/L)	46.1 (44.1, 48.4)	44.8 (42.1, 48.3)	0.078
BUN (mmol/L)	4.30 (3.60, 5.18)	3.85 (2.90, 5.00)	0.057
Creatinine (μmol/l)	60.50 (47.50, 76.55)	54.90 (41.70, 71.05)	0.158
C-reaction protein (mg/L)	24.89 (11.14, 57.54)	63.10 (23.57, 99.91)	0.008	0.185
BISAP	1 (0, 1)	2 (1, 2)	< 0.001	0.001
APACHE II	4 (2, 5)	5 (4, 8)	< 0.001	0.119

Data are presented as n (%) prevalence, and mean ± SD or median (interquartile range). WBC: White blood cells; MPV: Mean platelet volume; RDW: Red cell distribution width; ALT: Alanine aminotransferase; AST: Aspartate transaminase; BUN: Blood urea nitrogen; BISAP: Bedside index for severity in acute pancreatitis; APACHE II: Acute Physiology and Chronic Health Evaluation II; POF: Persistent organ failure.

Table 2 Overall accuracy of red cell distribution width (RDW), bedside index for severity in acute pancreatitis (BISAP), acute physiology and chronic health evaluation II, and BISAP plus RDW score for predicting persistent organ failure in patients with hypertriglyceridemia-induced acute pancreatitis on admission

Variable	AUC	Cut-off	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
RDW	0.85	13.1	82.4	77.9	65.1	89.8
BISAP	0.82	2	64.7	82.4	64.7	82.4
APACHE II	0.74	5	73.5	60.3	48.1	82.0
BR	0.89	2	91.2	67.6	58.5	93.9

HTG-AP: Hypertriglyceridemia-induced acute pancreatitis; AUC: Area under the curve; PPV: Positive predictive value; PPV: Negative predictive value; RDW: Red cell distribution width; BISAP: Bedside index for severity in acute pancreatitis; APACHE II: Acute Physiology and Chronic Health Evaluation II; BR: BISAP plus RDW.