Effects of tap water, electrolyte solution, and spontaneous and furosemide-stimulated urinary excretion on thirst

Figure 1 Thirst ratings by volunteers before and after volume depletion by 1. 7 L (top) and before and after intake of 600 mL of tap water (bottom). Previous volume depletion with diuretics did not statistically affect the thirst response to the intake of tap water. Median values are marked. Volume depletion was only performed in half of the experiments.

Figure 2 Volume depletion by furosemide increased thirst only in volunteers who were thirsty before volume depletion was initiated (left); conversely, intravenous infusion of Ringer’s acetate solution (middle) and ingestion of tap water (right) decreased thirst only in those who were thirsty before the respective provocation (challenge) of the fluid balance.