Serum bicarbonate may independently predict acute kidney injury in critically ill patients: An observational study

doi:10.5492/wjccm.v4.i1.71

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 4, Issue 1

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5532)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

418

WORD

282

HTML

3259

Figures (1-1)

242

Tables (1-3)

209

Sum=4410

Feb 4, 2015 (publication date) through Jan 6, 2025

Times Cited of This Article

Times Cited (9)

Journal Information of This Article

Publication Name

World Journal of Critical Care Medicine

ISSN

2220-3141

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Crit Care Med. Feb 4, 2015; 4(1): 71-76
Published online Feb 4, 2015. doi: 10.5492/wjccm.v4.i1.71

Table 1 Comparison of demographical and clinical characteristics at the time of admission to intensive care

	NO AKI(n = 1006)	AKI(n = 877)	P value
Age (yr)	61.4 (18.8)	66.2 (16.6)	< 0.0001
Sex, M:F	1.1:1 (726:662)	1.1:1 (242:220)	0.978
Requirement for mechanical ventilation	46%	51.5%	0.01
Severity of illness
APACHE III	47.8 (25.3)	63 (35.7)	< 0.0001
SAPS II	33.7 (13.8)	45.9 (17.6)	< 0.0001
Vital signs
Heart rate (/min)	99 (22)	105 (23)	< 0.001
Respiratory rate (/min)	24 (6.6)	26 (7.5)	< 0.001
Temperature¹ (°C)	35.3 (0.9)	35.2 (1.2)	0.004
Systolic BP¹ (mmHg)	102.9 (16.8)	96.5 (169)	< 0.001
Diastolic BP¹ (mmHg)	55.8 (12.2)	52.3 (12.7)	< 0.001
MAP (mmHg)	71.3 (12.7)	67.0 (12.8)	< 0.001

¹Lowest. Data are presented in mean ± SD; number of patients where data were available for analyses. SAPS II: Simplified acute physiology score II; APACHE III: Acute physiology age and chronic health evaluation III; BP: Blood pressure; MAP: Mean arterial pressure.

Table 2 Comparison of laboratory characteristics at the time of admission to intensive care

	NO AKI(n = 1006)	AKI(n = 877)	P value
pH	7.4 (0.08)	7.3 (0.12)	< 0.001
PaCO₂ (mmHg)	41 (11.3)	40 (13.7)	0.005
PaO₂, (mmHg)	116 (85.4)	113 (79.7)	0.5
HCO₃ (mmol/L)	23.5 (3.7)	20.1 (5.3)	< 0.001
Sodium (mmol/L)	141 (4.2)	141 (5.3)	0.7
Potassium (mmol/L)	4.5 (0.6)	4.7 (0.8)	< 0.001
Urea (μmol/L)	6.2 (3.9)	14.4 (10.6)	< 0.0001
Baseline Creatinine (μmol/L)	72 (36.8)	180 (173.6)	< 0.001
Peak creatinine (μmol/L)¹	76 (36.6)	196 (175.3)	< 0.001
Serum albumin (g/L)	35 (6.1)	34 (6.1)	0.001
Blood glucose (mmol/L)	8.9 (3.4)	11.1 (5.7)	< 0.001
Lactate (mmol/L)	2.1 (2.0)	3.4 (3.1)	< 0.001
White cell count (× 10⁹/L)	12.9 (9.6)	15.6 (10.8)	< 0.001
Hematocrit (%)	0.36 (0.057)	0.34 (0.061)	< 0.001

¹During first 48 h of ICU admission. Data are presented in mean ± SD. ICU: Intensive care unit.

Table 3 Comparison of outcomes

	NO AKI(n = 1006)	AKI(n = 877)	P value
Died in hospital (%)	30.9	69.1	< 0.001
Death in ICU (%)	57.0	43.0	< 0.001
Hospital length of stay (d)	12.6 (20.1)	14.5 (16.3)	0.02
ICU length of stay (d)	2.8 (4.1)	4.4 (5.7)	< 0.001

Data are presented in mean ± SD. ICU: Intensive care unit.

Citation: Gujadhur A, Tiruvoipati R, Cole E, Malouf S, Ansari ES, Wong K. Serum bicarbonate may independently predict acute kidney injury in critically ill patients: An observational study. World J Crit Care Med 2015; 4(1): 71-76
URL: https://www.wjgnet.com/2220-3141/full/v4/i1/71.htm
DOI: https://dx.doi.org/10.5492/wjccm.v4.i1.71