Serum bicarbonate may independently predict acute kidney injury in critically ill patients: An observational study

doi:10.5492/wjccm.v4.i1.71

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394

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Feb 4, 2015 (publication date) through Aug 24, 2024

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World Journal of Critical Care Medicine

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2220-3141

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Crit Care Med. Feb 4, 2015; 4(1): 71-76
Published online Feb 4, 2015. doi: 10.5492/wjccm.v4.i1.71

Table 1 Comparison of demographical and clinical characteristics at the time of admission to intensive care

	NO AKI(n = 1006)	AKI(n = 877)	P value
Age (yr)	61.4 (18.8)	66.2 (16.6)	< 0.0001
Sex, M:F	1.1:1 (726:662)	1.1:1 (242:220)	0.978
Requirement for mechanical ventilation	46%	51.5%	0.01
Severity of illness
APACHE III	47.8 (25.3)	63 (35.7)	< 0.0001
SAPS II	33.7 (13.8)	45.9 (17.6)	< 0.0001
Vital signs
Heart rate (/min)	99 (22)	105 (23)	< 0.001
Respiratory rate (/min)	24 (6.6)	26 (7.5)	< 0.001
Temperature¹ (°C)	35.3 (0.9)	35.2 (1.2)	0.004
Systolic BP¹ (mmHg)	102.9 (16.8)	96.5 (169)	< 0.001
Diastolic BP¹ (mmHg)	55.8 (12.2)	52.3 (12.7)	< 0.001
MAP (mmHg)	71.3 (12.7)	67.0 (12.8)	< 0.001

¹Lowest. Data are presented in mean ± SD; number of patients where data were available for analyses. SAPS II: Simplified acute physiology score II; APACHE III: Acute physiology age and chronic health evaluation III; BP: Blood pressure; MAP: Mean arterial pressure.

Table 2 Comparison of laboratory characteristics at the time of admission to intensive care

	NO AKI(n = 1006)	AKI(n = 877)	P value
pH	7.4 (0.08)	7.3 (0.12)	< 0.001
PaCO₂ (mmHg)	41 (11.3)	40 (13.7)	0.005
PaO₂, (mmHg)	116 (85.4)	113 (79.7)	0.5
HCO₃ (mmol/L)	23.5 (3.7)	20.1 (5.3)	< 0.001
Sodium (mmol/L)	141 (4.2)	141 (5.3)	0.7
Potassium (mmol/L)	4.5 (0.6)	4.7 (0.8)	< 0.001
Urea (μmol/L)	6.2 (3.9)	14.4 (10.6)	< 0.0001
Baseline Creatinine (μmol/L)	72 (36.8)	180 (173.6)	< 0.001
Peak creatinine (μmol/L)¹	76 (36.6)	196 (175.3)	< 0.001
Serum albumin (g/L)	35 (6.1)	34 (6.1)	0.001
Blood glucose (mmol/L)	8.9 (3.4)	11.1 (5.7)	< 0.001
Lactate (mmol/L)	2.1 (2.0)	3.4 (3.1)	< 0.001
White cell count (× 10⁹/L)	12.9 (9.6)	15.6 (10.8)	< 0.001
Hematocrit (%)	0.36 (0.057)	0.34 (0.061)	< 0.001

¹During first 48 h of ICU admission. Data are presented in mean ± SD. ICU: Intensive care unit.

Table 3 Comparison of outcomes

	NO AKI(n = 1006)	AKI(n = 877)	P value
Died in hospital (%)	30.9	69.1	< 0.001
Death in ICU (%)	57.0	43.0	< 0.001
Hospital length of stay (d)	12.6 (20.1)	14.5 (16.3)	0.02
ICU length of stay (d)	2.8 (4.1)	4.4 (5.7)	< 0.001

Data are presented in mean ± SD. ICU: Intensive care unit.

Citation: Gujadhur A, Tiruvoipati R, Cole E, Malouf S, Ansari ES, Wong K. Serum bicarbonate may independently predict acute kidney injury in critically ill patients: An observational study. World J Crit Care Med 2015; 4(1): 71-76
URL: https://www.wjgnet.com/2220-3141/full/v4/i1/71.htm
DOI: https://dx.doi.org/10.5492/wjccm.v4.i1.71