Variable change in renal function by hypertonic saline

Table 1 Baseline characteristics by saline type

Variable	23.40%(n = 22)	3%(n = 13)	NS/LR(n = 194)	P value
Diagnosis				0.078
ICH	15 (68)	7 (54)	67 (35)
Other	3 (14)	3 (23)	47 (24)
SAH	4 (18)	2 (15)	43 (22)
Stroke	0 (0)	0 (0)	28 (14)
TBI	0 (0)	1 (8)	9 (5)
Age (yr)	61.9 ± 15.6	59.2 ± 19.6	56.8 ± 16.2	0.356
HCT (mmHg)	38.2 ± 6.9	38.1 ± 6.2	38.1 ± 7.0	0.999
WBC (109/L)	12.5 ± 6.2	11.6 ± 5.2	11.4 ± 9.1	0.865
Temperature (°C)	37.3 ± 0.9	37.2 ± 0.7	36.8 ± 2.5	0.514
HR	81.3 ± 20.3	86.5 ± 19.1	82.6 ± 16.7	0.668
RR	18.1 ± 4.6	17.5 ± 7.3	18.6 ± 4.4	0.633
MAP	98.3 ± 18.2	100.8 ± 33.2	106.5 ± 24.8	0.267
Na	141.5 ± 6.4	8.2 ± 5.3	139.0 ± 4.1	0.037
K	3.9 ± 0.6	3.7 ± 0.5	4.0 ± 2.0	0.888
Glasgow coma Scale (verbal)	2.6 ± 1.7	2.3 ± 1.5	3.4 ± 1.7	0.010
1	10 (45)	6 (46)	53 (27)
2	1 (5)	2 (15)	10 (5)
3	2 (9)	1 (8)	15 (8)
4	5 (23)	3 (23)	29 (15)
5	4 (18)	1 (8)	87 (45)
Glasgow Coma Scale (motor)	5.0 ± 1.5	3.9 ± 1.8	5.3 ± 1.3	0.002
1	1 (5)	1 (8)	5 (3)
2	1 (5)	3 (23)	4 (2)
3	2 (9)	2 (15)	16 (8)
4	2 (9)	1 (8)	13 (7)
5	4 (18)	2 (15)	27 (14)
6	12 (55)	4 (31)	129 (66)
Glasgow coma Scale (eyes)	2.9 ± 1.3	2.0 ± 1.0	3.3 ± 1.1	< 0.001
1	5 (23)	5 (38)	28 (14)
2	4 (18)	4 (31)	15 (8)
3	2 (9)	3 (23)	31 (16)
4	11 (50)	1 (8)	120 (62)
A aGrad1	6.1 ± 195.3	173.7 ± 141.2	125.3 ± 154.9	0.024
pH2	7.4 ± 0.1	7.4 ± 0.1	7.4 ± 0.1	0.306
PCO23	27.0 ± 1.7	27.0 ± 3.0	26.0 ± 3.3	0.756
PaO2	209.2 ± 114.6	189.5 ± 136.8	150.8 ± 115.1	0.053
Baseline Cr	1.3 ± 1.4	0.9 ± 0.3	1.4 ± 1.8	0.655
APACHE II	14.9 ± 7.6	17.5 ± 5.2	10.7 ± 6.5	< 0.001

¹23.4%, n = 19; 3%, n = 12; normal saline/ringer’s lactate (NS/LR), n = 177;

²23.4%, n = 19; 3%, n = 10; NS/LR, n = 111;

³23.4%, n = 3; 3%, n = 3; NS/LR, n = 83. ICH: Intracerebral hemorrhage; TBI: Traumatic brain injury; SAH: Subarachnoid hemorrhage; HCT: Hematocrit; MAP: Mean arterial pressure; APACHE II: Admission acute physiology and chronic health evaluation II scores.

Table 2 Pairwise comparisons for those that were significant

Dependent	23.4% vs 3%	23.4% vs NS/LR	3% vs NS/LR
Na+	0.035	0.016	0.503
A aGrad	0.370	0.009	0.306
Apache II	0.261	0.005	< 0.001
GCS v	0.579	0.034	0.019
GCS m	0.027	0.294	< 0.001
GCS E	0.028	0.123	< 0.001

NS/LR: Normal saline/ringer’s lactate; APACHE II: Admission acute physiology and chronic health evaluation II scores; GCS: Glasgow coma scale.

Table 3 Correlations between Cl^-, Na⁺ and Cr

	Na+ and Cr			Cl- and Cr
Population	n	Corr	P value	n	Corr	P value
Overall	230	0.025	0.63	229	0.074	0.16
Saline type
23.40%	22	0.037	0.58	22	0.042	0.65
3%	13	0.256	0.26	13	0.181	0.43
NS/LR	194	0.026	0.65	194	0.097	0.09
Diagnosis type
ICH	89	0.145	0.10	89	0.058	0.55
Other	53	0.096	0.09	53	0.287	< 0.001
SAH	50	0.125	0.08	50	0.085	0.28
Stroke	28	0.187	< 0.001	28	0.185	0.001
TBI	10	0.447	0.048	10	0.361	0.1

NS/LR: Normal saline/ringer’s lactate; ICH: Intracerebral hemorrhage; TBI: Traumatic brain injury; SAH: Subarachnoid hemorrhage.