Perveen S, Srinivasan A, Prusty BSK, Jyotsna CV, Pabba S, Reddy R, Sheshala K, Ragavendra Asranna K. In-hospital new-onset seizures in patients admitted to the medical intensive care unit: An observational study and algorithmic approach. World J Crit Care Med 2024; 13(4): 97399 [DOI: 10.5492/wjccm.v13.i4.97399]
Corresponding Author of This Article
Arunkumaar Srinivasan, MBBS, MD, Academic Fellow, Critical Care Medicine, Virinchi Hospital, Banjara Hills Road 1, Hyderabad 500034, Telangāna, India. arundec06@gmail.com
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
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World J Crit Care Med. Dec 9, 2024; 13(4): 97399 Published online Dec 9, 2024. doi: 10.5492/wjccm.v13.i4.97399
Table 1 Demographics, baseline characteristics, and mean Sequential Organ Failure Assessment score
Admission characteristics
n of 61/2522
Percentage
Age in yr
18-30
11
18.03
31-50
30
49.18
51-70
20
32.78
Sex
Female
33
54.09
Male
28
45.90
Comorbidities
Diabetes mellitus
23
37.70
Hypertension
21
34.42
Coronary artery disease
12
19.67
Hypothyroidism
7
11.47
Mean Sequential Organ Failure Assessment score
11.48
No. of patients who died
15
24.59
Table 2 Etiology of new-onset seizures in the intensive care unit
Etiology
Total, n
Mortality, n
Metabolic
21
Hyponatremia
14
2
Hypocalcemia
3
1
Uremia
3
0
Hypoglycemia
1
0
Structural
5
Intracerebral bleed
2
2
Posterior reversible encephalopathy syndrome
3
0
Infective
17
Dengue
8
2
Leptospirosis
2
0
Scrub typhus
3
1
Septic encephalopathy
1
0
Viral encephalitis
3
1
Bacterial meningitis
1
1
Drug withdrawal
2
0
Drug-related
4
4
Toxicology
5
Organophosphorous poisoning
3
0
Herbicide poisoning
1
0
Benzodiazepine overdose
1
0
Others
4
Thrombotic thrombocytopenic purpura
3
1
Somatoform disorder
1
0
Unknown
2
0
Table 3 Binomial logistic regression analysis of the effects of sodium and calcium levels on seizure probability
Parameter
P value
Odds ratio
95%CI
Lower
Upper
Sodium
0.013
0.922
0.865
0.983
Calcium
0.005
0.109
0.023
0.520
Table 4 Logistic regression analysis for the prediction of death outcome using metabolic and clinical parameters
Parameter
P value
Odds ratio
95%CI
Lower
Upper
Sodium
0.051
1.101
1.000
1.212
Potassium
0.424
0.590
0.161
2.153
Calcium
0.764
1.415
0.146
13.716
Creatinine
0.668
1.059
0.816
1.374
Blood sugars
0.292
1.012
0.990
1.035
Length of stay in ICU
0.510
1.159
0.747
1.799
Citation: Perveen S, Srinivasan A, Prusty BSK, Jyotsna CV, Pabba S, Reddy R, Sheshala K, Ragavendra Asranna K. In-hospital new-onset seizures in patients admitted to the medical intensive care unit: An observational study and algorithmic approach. World J Crit Care Med 2024; 13(4): 97399