Remimazolam in intensive care unit: Potential applications and considerations

Table 1 Characteristics of remimazolam

Characteristics of remimazolam
Rapid onset of action with onset in 1-3 minutes, elimination Half-life 0.75 hour
Rapid offset due to break down by tissue esterase's and predictable recovery time
Less adjunct medication requirements like Fentanyl and faster neuropsychiatric recovery
Maintained respiratory and hemodynamic stability
Reversal agent available: Flumazenil
Induction and maintenance of procedural sedation bolus of 2.5-5 mg IV once and every 2 minutes as needed
General anesthesia or ICU sedation induction 6-12 mg/kg/h and maintenance 1-3 mg/kg/h

ICU: Intensive care unit.