Timing, method and discontinuation of hydrocortisone administration for septic shock patients

Figure 1 Change in maximal norepinephrine dose from 12 h after initiation of hydrocortisone. Comparison between continuous and bolus administration groups, with two-way mixed ANOVA test, P = 0.04.

Figure 2 Kaplan-Meier analysis comparing the rate of septic shock reversal, according to administration of hydrocortisone. At 7 d (168 h), 83% of continuous infusion patients were vasopressor-free compared to 63% of patients who were in the bolus administration group, P = 0.004.

Figure 3 Correlation between time to initiation of hydrocortisone and total time to shock reversal. Spearman correlation coefficient 0.80, P < 0.001.

Figure 4 Receiver operating characteristic curve analysis of time to initiation of hydrocortisone for prediction of shock reversal. AUC, 0.81, P < 0.0001. Cut-off obtained with Youden index. AUC: Area under the curve.