Regional dynamic cerebral autoregulation across anterior and posterior circulatory territories: A detailed exploration and its clinical implications

Figure 1 Lassen’s cerebral autoregulatory curve. Cerebral blood flow is normally reported to remain constant over a large mean arterial pressure range of 50-150 mmHg. This range is significantly shifted or narrower in patients with acute brain injury. The ischemic critical perfusion threshold is defined at 30 mL/100 g/min. This figure was generated using BioRender (Agreement No: SE269MFWGB).

Figure 2 Overview of neurovascular coupling and the blood-brain barrier. Proposed mechanisms of regional variations of cerebral autoregulation include reduced sympathetic nerve density, impaired endothelial function, impaired blood-brain barrier integrity, and CBF-metabolism uncoupling. This figure was generated using BioRender (Agreement No: JM26USH8 LZ).