On the immunological limitations of hibernation and synthetic torpor as a supporting technique for astronauts’ radioprotection in deep space missions

Figure 1 Hibernation (synthetic torpor) can lead to immune system dysregulation and the combination of dysregulated immune system and other factors such as increased bacterial virulence, presence of particles in suspension and radiation-induced antimicrobial resistance can be potentially life-threatening for astronauts. LPS: Lipopolysaccharides.