Subclinical hypothyroidism in atopic South Italian children

Table 1 Clinical and laboratory differences between atopic and not atopic children affected by allergic disease

	Atopic children	Not atopic children	P
Patients, n	459/732 (62.7%)	273/732 (37.3%)
Age expressed in years (mean age ± SD)	6.24 ± 3.55	5.82 ± 3.71	0.128
Gender (male)	245/459 (53.37%)	137/274 (50%)	0.37
Family history of atopy	365/420 (86.9%)	195/235 (80%)	0.17
Family history of thyroid disease	191/421 (45.36%)	94/235 (40%)	0.18
BMI (kg/m2)	16.6 (10.9-36.8)	16.4 (10.7-30.17)	0.069
SCH affected (%)	33/445 (7.41%)	13/260 (5%)	0.21
SCH obeses (%)	1/33 (3%)	1/13 (7.69%)	0.48
CRP (mg/dL)	0.06 (0-10.3)	0.08 (0-7.9)	0.123
TSH (UI/mL)	2.33 (0.35-12.2)	2.24 (0.52-6.98)	0.269

P value < 0.05 was considered significant. BMI: Body mass index; SCH: Subclinical hypothyroidism; CRP: C-reactive protein; TSH: Thyroid stimulating hormone.

Table 2 Atopic and not atopic children divided into three groups on the basis of the C-reactive protein serum levels

	Atopic children			P	Not atopic children			P
	Group 1	Group 2	Group 3		Group 1	Group 2	Group 3
CRP (mg/dL)	< 0.1	0.1-0.3	> 0.3-< 1		< 0.1	0.1-0.3	> 0.3-< 1
SCH	18/272 (6.62%)	7/121 (5.78%)	8/52 (15.38%)	10.033 OR: 2.57 (1.55-6.26) 30.04 OR 2.96 (1.01-8.65)	8/151 (5.29%)	3/81 (3.70%)	2/28 (7.14%)
C3 (mg/dL)	115 (20-174)	122 (50-172)	138 (103-192)	11.86e-820.027 30.00021	116.5 (10-170)	126 (73-177)	139 (109-170)	10.000053 20.0085 30.024
Total IgE (kUI/L)	120 (100-2270)	123.5 (100-4328)	162.1 (124-5000)	10.000017 30.00045	17.4 (1.9-98)	22.45 (1.9-93)	22.43 (1.9-88.9)

¹Group 1 vs group 3;

²Group 1 vs group 2;

³Group 2 vs group 3. SCH: Subclinical hypothyroidism; CRP: C-reactive protein.