Global research production in neonatal abstinence syndrome: A bibliometric analysis

Table 1 The top 10 countries contributed to publications in neonatal abstinence syndrome research (1958 to 2019)

SCR	Country	Number of documents (%)	h-index	No. of collaborated countries
1st	United States	833 (47.93)	71	38
2nd	Canada	112 (6.44)	29	14
3rd	United Kingdom	111 (6.39)	29	25
4th	Germany	77 (4.43)	17	23
5th	Italy	65 (3.74)	15	21
6th	Australia	63 (3.62)	26	7
7th	France	62 (3.57)	20	23
8th	Spain	59 (3.39)	18	22
9th	Austria	52 (2.99)	19	19
10th	the Netherlands	45 (2.59)	16	24

Table 2 The top 11 most productive journals on neonatal abstinence syndrome research from 1958 to 2019

SCR1	Journal	Frequency (%)	IF2
1st	Pediatrics	43 (2.47)	5.359
2nd	Journal of Pediatrics	34 (1.96)	3.700
3rd	Journal of Perinatology	33 (1.90)	1.967
4th	Drug and Alcohol Dependence	31 (1.78)	3.951
5th	Addiction	27 (1.55)	6.343
6th	Advances in Neonatal Care	23 (1.32)	1.405
6th	American Journal of Obstetrics and Gynecology	23 (1.32)	6.502
8th	Acta Paediatrica	22 (1.27)	2.111
9th	Archives of Disease in Childhood Fetal and Neonatal Edition	19 (1.09)	5.436
10th	Journal of Addiction Medicine	18 (1.04)	3.014
10th	Pediatric Research	18 (1.04)	2.747

¹If some journals receive the same ranking number, a gap is left in the next ranking numbers.

²Impact factors based on Journal Citation Reports 2019 adapted from Clarivate Analytics which was published in 2020.

IF: Impact factors.

Table 3 The first twelve authors by record count in neonatal abstinence syndrome research

SCR1	Author name	Country	Number of documents (%)
1st	Jones HE	United States	42 (2.42)
2nd	Fischer G	Austria	29 (1.67)
3rd	Jansson LM	United States	28 (1.61)
3rd	Patrick SW	United States	28 (1.61)
5th	Finnegan LP	United States	24 (1.38)
5th	Kaltenbach K	United States	24 (1.38)
5th	Wachman EM	United States	24 (1.38)
8th	Davis JM	United States	17 (0.98)
9th	Jagsch R	Austria	14 (0.81)
10th	Huestis MA	United States	12 (0.69)
10th	Koren G	Israel	12 (0.69)
10th	Raith W	Austria	12 (0.69)

¹If some authors receive the same ranking number, a gap is left in the next ranking numbers.

Table 4 The 20 Most-cited articles in neonatal abstinence syndrome based on the citation count

SCR	Ref.	Title	Year	Source title	Cited by
1st	Patrick et al[1]	Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009	2012	JAMA - Journal of the American Medical Association	529
2nd	Jones et al[43]	Neonatal abstinence syndrome after methadone or buprenorphine exposure	2010	New England Journal of Medicine	526
3rd	Hudak et al[40]	Neonatal drug withdrawal	2012	Pediatrics	443
4th	Finnegan et al[38]	Neonatal abstinence syndrome: assessment and management	1975	Addictive diseases	435
5th	Sanz et al[49]	Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: A database analysis	2005	Lancet	318
6th	Hughes et al[41]	Nicotine withdrawal vs other drug withdrawal syndromes: similarities and dissimilarities	1994	Addiction	253
7th	Patrick et al[9]	Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012	2015	Journal of Perinatology	251
8th	Levinson-Castiel et al[45]	Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants	2006	Archives of Pediatrics and Adolescent Medicine	238
9th	Costei et al[37]	Perinatal outcome following third trimester exposure to paroxetine	2002	Archives of Pediatrics and Adolescent Medicine	233
10th	Kocherlakota[2]	Neonatal abstinence syndrome	2014	Pediatrics	219
11th	Tolia et al[50]	Increasing incidence of the neonatal abstinence syndrome in United States neonatal ICUs	2015	New England Journal of Medicine	213
12th	American Academy of Pediatrics Committee on Drugs[36]	Neonatal drug withdrawal	1998	Pediatrics	212
13th	ACOG Committee on Health Care for Underserved Women and American Society of Addiction Medicine[35]	Committee opinion No. 524: Opioid abuse, dependence, and addiction in pregnancy	2012	Obstetrics and Gynecology	208
13th	Jones et al[42]	Buprenorphine vs methadone in the treatment of pregnant opioid-dependent patients: Effects on the neonatal abstinence syndrome	2005	Drug and Alcohol Dependence	208
15th	Wisner et al[51]	Pharmacologic treatment of depression during pregnancy	1999	Journal of the American Medical Association	200
16th	Zajecka et al[52]	Discontinuation symptoms after treatment with serotonin reuptake inhibitors: A literature review	1997	Journal of Clinical Psychiatry	197
17th	Nau et al[46]	Valproic acid and its metabolites: Placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers	1981	Journal of Pharmacology and Experimental Therapeutics	197
18th	Ryan et al[48]	Cocaine abuse in pregnancy: Effects on the fetus and newbornF	1987	Neurotoxicology and Teratology	181
19th	Lejeune et al[44]	Prospective multicenter observational study of 260 infants born to 259 opiate-dependent mothers on methadone or high-dose buprenophine substitution	2006	Drug and Alcohol Dependence	180
20th	Hadeed and Siegel[39]	Maternal cocaine use during pregnancy: Effect on the newborn infant	1989	Pediatrics	177
21st	Nordeng et al[47]	Neonatal withdrawal syndrome after in utero exposure to selective serotonin reuptake inhibitors	2001	Acta Paediatrica,	175

Table 5 List of most frequent drugs occurrences in neonatal abstinence syndrome literature

Drug	Number of publications
Methadone	629
Morphine	378
Buprenorphine	313
Phenobarbital	275
Diamorphine	212
Heroine	138
Cocaine	138
Clonidine	130
Diazepam	124
Alcohol	80
Cannabis	79
Chlorpromazine	76
Naloxone	62
Fentanyl	56