Conversion from prolonged intravenous fentanyl infusion to enteral methadone in critically ill children

Figure 1 Comparison of enteral methadone and intravenous fentanyl titration across groups in the study. A: Paired comparison of median enteral methadone doses (mg/kg) between rapid conversion group and slow conversion group at serial time points following initiation of enteral methadone (^aP < 0.05); B: Paired comparison of median intravenous fentanyl infusion doses (μg/kg per hour) between rapid conversion group and slow conversion group at serial time points following initiation of enteral methadone (^aP < 0.05). RCG: Rapid conversion group consisted of patients who were completely converted from fentanyl infusion directly to enteral methadone in 48 h or less; SCG: Slow conversion group consisted of patients who were completely converted from fentanyl infusion directly to enteral methadone in more than 48 h.

Figure 2 Paired comparison of median withdrawal (Withdrawal Assessment Tool-Version 1) scores between rapid conversion group and slow conversion group at serial time points following initiation of enteral methadone (^aP < 0. 05). RCG: Rapid conversion group consisted of patients who were completely converted from fentanyl infusion directly to enteral methadone in 48 h or less; SCG: Slow conversion group consisted of patients who were completely converted from fentanyl infusion directly to enteral methadone in more than 48 h. WAT-1: Withdrawal Assessment Tool-Version 1.