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Copyright ©The Author(s) 2016.
World J Respirol. Nov 28, 2016; 6(3): 69-75
Published online Nov 28, 2016. doi: 10.5320/wjr.v6.i3.69
Table 1 Case series and original studies of post-transarterial chemoembolization pulmonary complications
Ref.TimeNo.InfusionPulmonary complicationsOnsetRisk factors
Chung et al[42]01/1990-12/1991336 patientsIodized oil (3-40 mL) with Doxorubicin (20-60 mg)Any pulmonary symptoms: 11 (3.27%) Pulmonary oil embolism: 6 (1.79%) Death: 1 (0.3%)2-5 dIodized oil > 20 mL
Tajima et al[44]06/1997-05/199944 patientsLipiodol (0-10 mL) with Doxorubicin derivatives (0-50 mg)Dyspnea or hemoptysis: 2 (4.5%)Via right inferior phrenic artery
Sakamoto et al[45]1998850 patients 2300 proceduresIodized oil (2-15 mL) with drug mix, including Doxorubicin (10-30 mg)Pulmonary oil embolism: 4 (0.17%)Via right inferior phrenic artery
Xia et al[59]01/1997-02/20041348 patients 2012 proceduresLipiodol (5-40 mL) with Chemotherapeutic agentsPulmonary oil embolism: 1 (0.05%)6 hLipiodol 25 mL infusion
Wu et al[41]01/2005-12/2008219 patientsLipiodol (4-50 mL) with Doxorubucin (6-60 mg)Pulmonary oil embolism: 20 (9.1%) Death: 5 (2.3%)Lipiodol > 14.5 mL
Wu et al[60]01/2006-12/200689 patientsLipiodol (4-50 mL) without or with Doxorubicin (6-60 mg)Pulmonary oil embolism: 4 (4.5%)1 h-4 dLipiodol 20-50 mL infusion
Xu et al[40]01/2010-03/2012478 patients 1026 proceduresIodized oil (10-40 mL) with Epirubicin (20-60 mg)Pulmonary oil embolism: 11 (2.3%) Death: 3 (0.6%)0 h-2 dTumor size > 10 cm Lipiodol > 20 mL
Table 2 Post-transarterial chemoembolization pulmonary complications
Post-TACE pulmonary complicationsRef.
Pulmonary oil embolismLin et al[43]
Weng et al[61]
References from Table 1
Interstitial pneumonitisAdaddin et al[57]
Chemical pneumonitisKwok et al[62]
ALI/ARDSKhan et al[56]
Samejima et al[63]
Czauderna et al[64]
Hatamaru et al[47]
Toro et al[65]
Wu et al[60]
Nhu et al[1]
Lipoid pneumoniaTaupin et al[55]
Acute eosinophilic and neutrophilic pneumoniaAlifakioti et al[58]
Bilious pleuritisIchikawa et al[66]
Pulmonary abscessCubiella et al[67]
Pulmonary tumor embolismKwok et al[62]
Pulmonary metastasis with HCCLiou et al[49]