Review
Copyright ©2013 Baishideng Publishing Group Co.
World J Respirol. Nov 28, 2013; 3(3): 77-103
Published online Nov 28, 2013. doi: 10.5320/wjr.v3.i3.77
Table 1 Expression of lysophosphatidic acid receptor in pulmonary cell types and leukocytes
Cell typeLPAR1LPAR2LPAR3LPAR4LPAR5LPAR6Ref.
NHBEs++++++++-++[41]
NHBEs++++++++-+++[59]
NHBEs++++++-NANA[43]
HBE++++NANANANA[56]
HBE (BEAS-2B)++++++++++[59]
HBE (HBEpCs)++++++++NA[209]
HBE (HBEpCs)++++++NANANA[46]
HBE (HBEpCs)++++++NANANA[49]
HBE (HBEpCs)++++++NANANA[68]
Primary mouse tracheal EpCs+++++++++-NA[57]
NHBE cells++++++-NANA[43]
A549 alveolar epithelial carcinoma++NANANANANA[40]
A549 alveolar epithelial carcinoma++++--NANA[74]
NCI-H522 lung epithelial carcinoma-+++-NANA[74]
RLCNR rat lung adenocarcinomaNANA-NA++NA[283]
Primary mouse lung fibroblasts++++++++NA[31]
human fetal lung fibroblasts MRC5+++++++++NA[226]
Mouse embryonic fibroblasts++++++++++NA[101]
NHLFs CCL-151++++++++++[81]
NHLFs++++NANANANA[42]
Primary mouse lung endothelial+++-++++NA[31]
HPAECs+++++++++[106]
HMVECs+++++++++[106]
HEV ECsNANANA++NA++[116]
Human eosinophils+-+NANANA[148]
Primary mouse neutrophils-+++--+NA[31]
Primary mouse alveolar macrophages-++++NA[31]
Human alveolar macrophages+++++NANANA[158]
Rat alveolar macrophages+++-NANANA[158]
Human monocytes+--NANANA[176]
Mouse DCs++++++NANANA[58]
Human immature DCs+++NANANA[172]
Human mature DCs+++NANANA[172]
Human immature DCs-+-NANANA[174]
Human mature DCs-+-NANANA[174]
Mouse immature DCs+++++++++++NA[175]
Mouse mature DCs+++++++++NA[175]
Jurkat T cells++++-NANANA[178]
Jurkat T cells+++NANANA[295]
Human CD4 T cells++++NANANANA[177]
Human CD4 T cells++++-NANANA[176]
Human CD8 T cells---NANANA[176]
Mouse CD4 T cells+++++NA[31]
Mouse CD8 T cells++++++++NA[31]
Human B lymphocytes-++NANANA[176]
Human platelets+NA+NANANA[296]
Human platelets+++NANANA[295]
Human platelets+++++NA[297]
Human mast cells++++NANA[199]
Human mast cells+++-NANA[200]
Human mast cells-+++-+++++[201]
Lung resident mesenchymal stem cells+++++NANANA[298]
Table 2 Lysophosphatidic acid effects on different cell types
Cell typePrimarySpeciesLPA effectReceptorExperimentCarrierRef
Alveolar and bronchial epithelialYesMouseApoptosisLPAR1In vivoBiological fluid[41]
Alveolar and bronchial epithelialYesMouseApoptosisLPAR2In vivoBiological fluid[41,42]
NHBEsYesHuman(anchorage dependent) ApoptosisLPAR1In vitroFAF BSA[41]
NHBEsYesHumanTSLP, CCL20 inductionIn vitroNo[50]
NHBEsYesHumanTGF-β activationLPAR2In vitroNo[43]
NHBEsYesHumanInduction of Soluble ST2 expressionLPAR1,3In vitroNA[61]
Bronchial epithelial (HBEpCs)YesHumanEGFR transactivation, IL-8 secretionIn vitroBSA; BSA[46,49]
Bronchial epithelial (HBEpCs)YesHumanInduction of IL-13 Ralpha 2Gαi linkedIn vitroNo[54]
Bronchial epithelial (HBEpCs)YesHumanEpithelial barrier integrity enhancementLPAR1,3In vitroNA; BSA[56,209]
Bronchial epithelial (HBEpCs)YesHumanDecrease of EGFR-EGF bindingIn vitroBSA[66]
Bronchial epithelial (HBEpCs)YesHumanCOX-2 expression, PGE2 secretionGαi linkedIn vitroNo[63]
Bronchial epithelial (HBEpCs)YesHumanPDGFR-β transactivationIn vitroBSA[68]
Bronchial epithelial (HBEpCs)YesHumanc-Met redistribution on the membraneIn vitroNo[70,299]
Bronchial epithelial (BEAS-2B)NoHumanEGFR transactivationIn vitroBSA[66]
Bronchial epithelial (BEAS-2B)NoHumanRANTES inhibitionLPAR1In vitroFAF BSA[59]
R3/1 Alveolar epithelialNoRatInhibition of attachmentIn vitroFAF BSA[41]
Tracheal epithelialYesMouseCOX-2 expression, PGE2 secretionLPAR2In vitro/vivoNo[57]
H292 lung cancer epithelialNoHumanDecrease of EGFR-EGF bindingIn vitroBSA[66]
A549 alveolar epithelial carcinomaNoHumanDecrease of EGFR-EGF bindingIn vitroBSA[66]
A549 alveolar epithelial carcinomaNoHumanp53 decreaseIn vitroFAF BSA[73]
A549 alveolar epithelial carcinomaNoHumanCell migrationLPAR1In vitroBSA; BSA[40,74]
NCI-H522 lung epithelial carcinomaNoHumanCell motilityIn vitroBSA[74]
Fetal lung fibroblasts (HFL1)NoHumanChemotaxisIn vitroBiological fluid[31]
NLFs CCL151NoHumanProliferation, EGFR ectodomain sheddingGi/o linkedIn vitroNo[81]
Fetal lung fibroblasts MRC5NoHumanproliferationLPAR1,3In vitroNo[226]
Fetal lung fibroblasts IMR-90NoHumanChemotaxisLPAR1In vitro[95]
NLFsYesHumanDifferentiation, TGF-β expression and signalingLPAR2In vitroNo[42]
Lung fibroblastsYesMouseDifferentiation, TGF-β expression and signalingLPAR2In vitroNo[42]
Lung fibroblastsYesMouseChemotaxisLPAR1In vitroFAF BSA[31]
Lung fibroblastsYesMouseProtection from apoptosisLPAR1In vitroFAF BSA[41]
NIH 3T3 fibroblastsNoMouseProtection from apoptosis, proliferationGi linkedIn vitroFAF BSA[99]
NIH 3T3 fibroblastsNoMouseMigration, protection from apoptosis, proliferationIn vitroBSA[100]
Rat1/c-Myc fibroblastsNoRatProtection from apoptosisIn vitroFAF BSA[99]
Lung endothelialYesMouseVascular leak/extravasationLPAR1In vivoBiological fluid[31]
HPAECs pulmonary endothelialYesHumanIncrease of the endothelial layer permeabilityLPAR6In vitroFAF BSA[106]
BPAE pulmonary artery endothelialNoBovineMigration, chemotaxisIn vitroFAF BSA[127-129]
Smooth muscle cellsYesRabbit, catContractionEx vivoBSA[140]
HASM airway smooth muscle cellsYesHumanProliferation, stimulation of EGFR signalingIn vitroNA; BSA[139,141]
HASM airway smooth muscle cellsYesHumanActivation of TGF-βIn vitroNA[143]
Dendritic cellsYesMouseInhibition of activationLPAR2In vitro, in vivoFAF BSA[58]
Lung resident mesenchymal stem cellsYesHumanMigrationLPAR1In vitroNo[298]