Human ciliary muscle cell responses to kinins: Activation of ERK1/2 and pro-matrix metalloproteinases secretion

Figure 5 Effect of Bradykinin and FR-190997 on pro-matrix metalloproteinases generation in human ciliary muscle cells. The levels of pro-MMPs produced by h-CM cells following exposure to different concentrations of either BK or FR-190997 for 6 h were determined as described in the methods section. Results shown are mean ± SEM from n = 8 for pro-MMP-1 (A); n = 6-8 for pro-MMP-2 (B); n = 4-8 for pro-MMP-3 (C). ^aP < 0.05; ^bP < 0.01 relative to base-line controls by Student’s t-test. BK: Bradykinin; h-CM: Human ciliary muscle; pro-MMPs: Pro-matrix metalloproteinases.