Alpha1B adrenoceptor expression is a marker of reduced survival and increased tumor recurrence in patients with endometrioid ovarian cancer

Figure 1 Following immunostaining, adrenergic receptor proteins were seen as brown staining in ovarian cancer tissue. A: Strong α1B staining in a mucinous tumor; B: Strong α1B - high grade serous tumor; C: Moderate α2C - endometrioid tumor; D: Weak β2-AR - high grade serous tumor; E: Strong β2-AR - high grade serous tumor. AR: Adrenergic receptor.

Figure 2 High alpha1B protein expression (green curve) showed an association with poor survival (P = 0. 045) (A), and (B) tumor recurrence (P = 0.007) in the whole cohort of patients with ovarian cancer.

Figure 3 Four adrenoceptor groups were modelled for (A) ovarian cancer specific survival (P = 0. 284) and (B) tumor recurrence (P = 0.061) according to the relative expression of α1B and α2C. Group 1: α1B^positive/αα2C^positive; Group 2: α1B^positive/α2C^negative; Group 3: α1B^negative/α2C^positive; Group 4: α1B^negative/α2C^negative. Patients showing α1B expression (Groups 1 and 2) showed worse survival compared to patients that had α2C positive tumors without α1B expression.