Copyright
©The Author(s) 2015.
World J Hematol. Nov 6, 2015; 4(4): 54-68
Published online Nov 6, 2015. doi: 10.5315/wjh.v4.i4.54
Published online Nov 6, 2015. doi: 10.5315/wjh.v4.i4.54
Table 1 Overview of the storage lesions
| Lesions | Reversible or irreversible1 | |
| Biochemical | Loss of metabolic modulation | Reversible |
| Accumulation of lactate and pH drop | Reversible | |
| Ion leakage (K+) | Irreversible | |
| Decrease of antioxidant defenses | Reversible | |
| ATP-dependent protein function | Reversible | |
| Protein oxidation (sulfenic acid) | Reversible | |
| Protein oxidation (carbonylation)/degradation | Irreversible | |
| Membrame proteins (band 3 dimerization/accumulation of oxidized proteins) | Irreversible | |
| Hemolysis | Irreversible | |
| Lipid oxidation | Irreversible | |
| Morphological | Exposure of senescence markers (phosphatidylserine) | Irreversible |
| Shape change | Reversible or irreversible | |
| Reduced deformability | Irreversible | |
| Microvesiculation | Irreversible |
- Citation: Delobel J, Garraud O, Barelli S, Lefrère JJ, Prudent M, Lion N, Tissot JD. Storage lesion: History and perspectives. World J Hematol 2015; 4(4): 54-68
- URL: https://www.wjgnet.com/2218-6204/full/v4/i4/54.htm
- DOI: https://dx.doi.org/10.5315/wjh.v4.i4.54