Blood groups, hemoglobin phenotypes and clinical disorders of consanguineous Yansi population

Table 1 ABO, Rh and other phenotype frequencies in Yansi population and control subjects n (%)

	Yansin = 256	Controln = 269	P value
ABO phenotype			0.19
A	61 (23.8)	74 (27.5)
B	31 (12.1)	38 (14.1)
O	160 (62.5)	147 (54.7)
AB	4 (1.6)	10 (3.7)
Rh phenotype			0.27
ccD.ee	183 (71.5)	190 (70.6)
ccD.Ee	31 (12.1)	42 (15.6)
ccD.EE	0	3 (1.1)
CcD.ee	31 (12.1)	22 (8.2)
CcD.Ee	3 (1.2)	1 (0.4)
CCD.ee	1 (0.4)	1 (0.4)
ccddee	7 (2.7)	10 (3.7)
Kell phenotype
K+k-	0	0
K+k+	0	0
K-k+	256 (100)	269 (100)
Duffy phenotype
Fy (a+b+)	0	0
Fy (a-b+)	0	0
Fy (a+b-)	0	0
Fy (a-b-)	256 (100)	269 (100)
Kidd phenotype			0.096
Jk (a+b+)	96 (37.5)	81 (30.1)
Jk (a+b-)	141 (55.1)	173 (64.3)
Jk (a-b+)	19 (7.4)	15 (5.6)
MN phenotype			0.0021
MM	94 (36.7)	124 (46.1)
MN	123 (48.1)	89 (33.1)
NN	39 (15.2)	56 (20.8)
Ss phenotype			0.0006
SS	10 (3.9)	35 (13.0)
Ss	39 (15.2)	38 (14.1)
ss	204 (79.7)	187 (69.5)
S-s-	3 (1.2)	9 (3.4)

Table 2 Distribution of glucose-6-phosphate dehydrogenase and hemoglobin phenotype in Yansi population and control subjects n (%)

	Yansin = 256	Controln = 269	P value
G6PD			0.74
Normal	226 (88.3)	235 (87.4)
Deficient	30 (11.7)	34 (12.3)
Hemoglobin			0.24
AA	200 (78.1)	221 (82.2)
AS	56 (21.9)	48 (17.8)

G6PD: Glucose-6-phosphate dehydrogenase deficiency.

Table 3 Distribution of glucose-6-phosphate dehydrogenase deficiency in relation to gender in Yansi population and control subjects n (%)

Population	Male	Female	P value
Yansi (n = 256)			0.83
G6PD normal	101 (44.7)	125 (55.3)
G6PD deficient	14 (46.7)	16 (53.3)
Control (n = 269)			0.023
G6PD normal	117 (49.8)	118 (50.2)
G6PD deficient	24 (70.6)	10 (29.4)

G6PD: Glucose-6-phosphate dehydrogenase deficiency.

Table 4 Clinical disorders observed in the two populations n (%)

Clinical disorders	Yansin = 256	Controln = 269	P value
	M = 115; W = 141	M = 141; W = 128
Asthma	8 (3.1)	-	-
Rheumatism	20 (7.8)	-	-
Paralysis	2 (0.8)	-	-
Sterility	1 (1.4)	-	-
Sexual impotence	1 (0.4)	-	-
Epilepsy	13 (5.1)	-	-
Deafness	1 (0.4)	-	-
Miscarriage	46 (32.6)1	3 (2.3)1	< 0.0001
Stilbirth	4 (2.8)1	-	-
Death in young age	62 (24.2)	3 (2.3)	< 0.0001

¹Percentage among women of childbearing age. M: Men; W: Women.