Pathogenesis and diagnosis of contact dermatitis: Applications of reflectance confocal microscopy

Figure 1 Reflectance confocal microscopy image (0. 5 mm × 0.5 mm). A: Shows preservation of the stratum corneum in early stages of allergic dermatitis with parakeratotic corneocytes (yellow arrow) between skin folds (sf); B: Shows disruption (d) with early parakeratosis of the stratum corneum in irritative contact dermatitis.

Figure 2 Image. A: Vivablock image (4 mm × 4 mm) shows the spinous layer in a process of allergic contact dermatitis. Note the presence of multiple microvesicles (dashed circle); B: Reflectance confocal microscopy image (0.5 mm × 0.5 mm) reveals spongiosis and exocytosis (yellow arrow); in addition, microvesicle with lymphocytes inside (red arrow).