Clinical pharmacology of intravenous paracetamol in perinatal medicine

Table 1 Median paracetamol clearance estimates as reported in different cohorts of adults

Ref.	Dose	Adults	Paracetamol (L/h)
Owens et al[11]	1 g, repeated q6h	20 patients, major abdominal surgery
		Day 1 of surgery	10.8
		Day 2 or 3 after surgery	16.65
Kulo et al[14]	2 g iv, followed by 1g, q6h	Caesarean delivery, 39 women	21.1
	2 g iv, single dose	8/39, paired analysis, 18 wk postpartum	11.7
Liukas et al[21]	1 g, single dose	40 patients, different age cohort, orthopedic surgery
		20-40 years, median weight 81 kg	22.3
		60-70 years, median weight 83 kg	20.9
		70-80 years, median weight 82 kg	16.2
		80-90 years, median weight 68 kg	13.5
de Maat et al[22]	1 g iv, repeated dose	38 medium and intensive care unit adult patients	23.65
		26/38, medium care	20.84
		12/38, intensive care	39.78
Gregoire et al[30]	2 g iv, followed by 1g, q6h	26 healthy male and female volunteers	15.9
Depré et al[31]	0.5 g iv, single dose	12 healthy male volunteers	20.04