Assessment of palmar subcutaneous tissue vascularization in patients with Dupuytren’s contracture

doi:10.5312/wjo.v9.i9.130

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Sep 18, 2018 (publication date) through Jul 21, 2024

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World Journal of Orthopedics

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Basic Study

World J Orthop. Sep 18, 2018; 9(9): 130-137
Published online Sep 18, 2018. doi: 10.5312/wjo.v9.i9.130

Table 1 Characteristics of Dupuytren’s contracture patients (n = 87) n (%)

Parameter	Value
Demographic characteristics
Age (M ± σ) (min-maх)	(59 ± 10) (24-83)
Male:Female relation	8:01
Status localis
Frequency of bilateral affection	28 (32, 18)
Duration of disease, years – (min-max) - Me (Q1; Q3)	(0.5-20) - 5 (4; 10)
Level of contracture – (min-max) - Me (Q1; Q3)	(2-4) - 2.5 (2; 3)
Number of fingers with impaired function (Min-max) - Me (Q1; Q3)	(1-8) - 2 (1-2)
Comorbid conditions
Arterial hypertension	41 (47.1)
Ischemic heart disease	5 (5.7)
Chronic cardial insufficiency	3 (3.4)
Postinfarction cardiosclerosis	2 (2.3)
Diabetes type 2	4 (4.6)
Chronic obstructive pulmonary disease	6 (7.8)
Chronic hepatitis	6 (7.8)
Neuritis of the auditory nerve	4 (4.6)
Urolithiasis disease	2 (2.3)
Obesity	2 (2.3)
Extremal active smoking	7 (8.0)

Table 2 Morphometric characteristics of palmar fascia perforating arteries in healthy control and Dupuytren’s contracture groups [Me (Q1/Q3)]

Group/parameters	Healthy control n = 3	Y-group (< 55 yr of age) n = 8	O-group (≥ 55 yr of age) n = 19
Diameter	412.8	31566 (306.96/326.91)^a^c	334.85 (309.06/441.19)^a
of artery (μm)	(351.43/506.31)	P₂ = 0.000332; P₃ = 0.136006	P₁ = 0.010485
Lumen	243.15	151.56 (94.72/153.90)^a^c	178.19 (113.78/246.52)^a
diameter (μm)	(223.07/326.52)	P₂ = 0.000736; P₃ = 0.249671	P₂ = 0.007253
Wall thickness (μm)	89.03	92.16 (80.88/106.12)^c	117.98 (98.37/133.13)^a
Wall thickness (μm)	(65.97/88.88)	P₂ = 0.49959; P₃ = 0.010846	P₂ = 0.004483
Thickness	8.41	22.26 (14.79/33.42)^a	25.37 (21.16/41.75)^a
of intima (μm)	(7.80/0.82)	P₂ = 0.004998; P₃ = 0.355126	P₂ = 0.000463
Thickness	58.45	46.52 (38.08/60.30)	46.77 (38.26/64.03)
of media (μm)	(44.01/60.28)	P₂ = 0.37436; P₃ = 0.924826	P₂ = 0.17192
Intima/media thickness ratio	0.18	0.53 (0.25/0.55)^a	0.68 (0.33/0.96)^a
Intima/media thickness ratio	(0.12/0.24)	P₂ = 0.001992; P₃ = 0.282078	P₂ = 0.000198

^aP < 0.05 vs Healthy control;

^cP < 0.05 vs O-group.

Table 3 Stereologic characteristics of hypodermis from Dupuytren’s contracture patients

Group/parameters	Y-group (< 55 yr of age) n = 15	O-group (≥ 55 yr of age) n = 14
Percentage of adipoсytes in serial sections of Dupuytren’s tissue sample [Me (Q1/Q3), %]	35.05 (23.40/40.09)^aP₁ = 0.000338	27.79 (19.37/32.82)
Numerical microvessels density [Me (Q1/Q3), μm^-2]	5 (4/7)^aP₂ = 0	3 (2/4)
Volumetric microvessels density [Me (Q1/Q3), %]	2.48 (1.44/4.13)^aP₂ = 8.88 × 10-16	1.16 (0.52/2.12)
Relative number of microvessels with signs of periadventitial inflammatory infiltration	21.84^aP₂ = 1.69 × 10-5	12.93
Relative number of microvessels with signs of adventitial fibrosis	4.48^aP₂ = 0.002358	8.19
Microvessels diameters [Me (Q1/Q3), μm]	12.55 (9.26/18.05)^aP₂ = 0.019425	11.58 (8.67/16.84)

^aP < 0.05 vs O-group.

Table 4 Parameters of microcirculatory flow and post-occlusive hyperemia test in Dupuytren’s contracture patients in younger (DCY) and older (DCO) groups and healthy controls (Norm) in different age groups [Me (Q1/Q3)]

Parameters	Norm (25-54 yr of age)n = 22	DCY (< 55 yr of age)n = 6	Norm (55-70 yr of age)n = 6	DCO (≥ 55 yr of age)n = 18
Age	33 (23/54)	52 (45/54)	59 (55/63)	66 (59/69)
Microcirculatory flow base (PU)	4 (3.5/5.7)	15.45^c (8.4/20.6) P₃ = 0.020	3.5 (2.55/4.7)	4.15^a (3.1/7.8) P₂ = 0.019
Microcirculatory flow peak (PU)	14.7 (11.8/18.3)	27.5^c (22.2/44.4) P₃ = 0.002	18.2 (8.15/18.7)	20.1 (16.7/24.6)
Microcirculatory flow peak index (%)	340 (232/443)	218.5 (125/488)	373 (223/449)	508 (336/544) P₂ = 0.045
Time of hyperemic response (s)	15 (10/25)	17.5 (10/30)	20 (20/25)	20 (15/90)
Velocity of hyperemic response (PU/s)	0.62 (0.50/0.81)	0.56 (0.14/1.19)	0.52 (0.15/0.55)	0.81 (0.21/1.09)
Time of half-recovery (s)	45 (15/75)	30 (5/60)	35 (20/70)	40 (30/130)
Speed of half-recovery (PU/s)	0.18 (0.14/0.34)	0.96 (0.16/1.54)	0.2 (0.11/0.28)	0.28 (0.09/0.49)
Time of full recovery (s)	247 (205/380)	212 (40/600)	147 (125/190)	400 (90/600)
Duration of hyperemic response (s)	270 (180/300)	242 (55/660)	165 (150/210)	515 (120/700)
Intensity (area) of hyperemic response (relative units)	1127 (705/1830)	2799 (193/6216)	1575 (474/2202)	3804 (1110/5084)

^aP < 0.05 vs DCY;

^cP < 0.05 vs corresponding norm. DCY: Dupuytren’s contracture patients in younger; DCO: Dupuytren’s contracture patients in older.

Citation: Shchudlo N, Varsegova T, Stupina T, Dolganova T, Shchudlo M, Shihaleva N, Kostin V. Assessment of palmar subcutaneous tissue vascularization in patients with Dupuytren’s contracture. World J Orthop 2018; 9(9): 130-137
URL: https://www.wjgnet.com/2218-5836/full/v9/i9/130.htm
DOI: https://dx.doi.org/10.5312/wjo.v9.i9.130