Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines

Table 1 Bone volume/total volume and trabecular thickness mean values across the different groups (decalcified specimens)

	N	mean	SD	P-value vs No-t	P-value vs t-NS	P-value vs t-VEGF-n
BV/TV
No-t	5	29497	12265	-	NS	NS
t-NS	5	30902	6672	NS	-	NS
t-VEGFn	5	35220	5256	NS	NS	-
t-VEGFpump-n	5	48250	6869	0.006	0.013	NS
t-VEGFpump-μ	5	47077	4677	0.011	0.023	NS
t-VEGFμ	5	50450	6181	0.002	0.004	0.036
Total	30	40233	11039
TbTh
No-t	5	107776	35146	-	NS	NS
t-NS	5	107149	35711	NS	-	NS
t-VEGFn	5	108195	19986	NS	NS	-
t-VEGFpump-n	5	142307	28107	0.380	0.361	NS
t-VEGFpump-μ	5	156875	21965	0.088	0.082	NS
t-VEGFμ	5	151445	19065	0.161	0.151	0.168
Total	30	128958	33361

Statistically significant differences for BV/TV are provided as estimated after the Tukey’s HSD criterion while non-significant differences and denoted as “NS” or not shown. The same P-values are reported for TbTh for comparative reasons. BV/TV: Bone volume/total volume; TbTh: Trabecular thickness; VEGF: Vascular endothelial growth factor; NS: Not significant.

Table 2 Bone volume/total volume and trabecular thickness mean values across the different groups on the totality of specimens (decalcified and non-decalcified)

	N	mean	SD	P-value vs No-t	P-value vs t-NS	P-value vs t-VEGF-n
BV/TV
No-t	7	26739	11135	-	NS	NS
t-NS	5	30902	6672	NS	-	NS
t-VEGFn	7	38853	7591	NS	NS	-
t-VEGFpump-n	7	47485	7009	< 0.001	0.011	NS
t-VEGFpump-μ	7	44634	6638	0.002	0.053	NS
t-VEGFμ	7	48005	6573	< 0.001	0.008	0.27
Total	40	39863	11013
TbTh
No-t	7	97891	33316	-	NS	NS
t-NS	5	107149	35711	NS	-	NS
t-VEGFn	7	120315	26799	NS	NS	-
t-VEGFpump-n	7	147738	28295	0.020	0.145	NS
t-VEGFpump-μ	7	149884	22642	0.014	0.111	NS
t-VEGFμ	7	148194	16770	0.018	0.137	0.42
Total	40	129597	33360

Statistically significant differences are provided as estimated after the Tukey’s HSD criterion while non-significant differences and denoted as NS or not shown. The same P-values are reported for TbTh for comparative reasons. BV/TV: Bone volume/total volume; TbTh: Trabecular thickness; VEGF: Vascular endothelial growth factor; NS: Not significant.