Rheumatoid arthritis susceptibility genes: An overview

Table 1 The most relevant alleles associated with susceptibility in rheumatoid arthritis according to genome wide association studies

Gene candidate	Locus	SNP	OR
HLA-DRB1
PTPN22	1	Rs2476601	1.23-1.75
PADI4	1	Rs 2240340a	1.4
STAT4 T/C	2	Rs1188934	1.22 (0.98-1.53)
FCGR2A	1	Rs12746613	1.1
CTLA4	2	Rs3087243	0.75-1.136
CCL21	9	Rs2812378	1.1
TRAF1	9	Rs3761847	1.1 (0.97-1.32)
IRF5	7	Rs10488631	1.16 (0.72-1.87)
CCR6	6	Rs3093023	0.79 (0.64-0.98)
CD40	20	Rs4810485	0.91-1.02
IL2RA	10	Rs2104286	0.92

RA: Rheumatoid arthritis; HLA: Human leukocyte antigen; IL: Interleukin; PTPN22: Protein tyrosine phosphatase, nonreceptor type 22; TRAF1: Tumor necrosis factor receptor associated factor 1.