Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2 years follow-up

Table 1 Demographic characteristics of the study population, n (%)

Parameters	Group A (n = 25)	Group B (n = 25)	P value
Age (yr)			0.95
31–40	3 (12)	4 (16)
41–50	6 (24)	5 (20)
51–60	7 (28)	8 (32)
61–70	9 (36)	8 (32)
Sex			0.57
Male	12 (48)	14 (56)
Female	13 (52)	11 (44)
BMI			0.94
18.5-24.9	9 (36)	9 (36)
25.0-29.9	8 (32)	9 (36)
30.0-35.0	8 (32)	7 (28)
K-L grading			0.58
II	11 (44)	13 (52)
III	14 (56)	12 (48)

Chi-square test. BMI: Body mass index.

Table 2 Visual analog score in various time-points

Time-point	Group A (n = 23)	Group B (n = 24)	Standard error	95%CI	t	P value
Pre-procedure	7.7 ± 1.1	7.8 ± 0.8	0.272	-0.44-0.64	0.37	0.71
1 month Follow-up	7.0 ± 1.8	7.2 ± 1.0	0.41	-0.62-1.02	0.48	0.561
3 months Follow-up	6.5 ± 1.8	7.6 ± 1.6	0.48	0.13-2.06	2.28	0.03
6 months Follow-up	4.3 ± 1.4	6.8 ± 1.2	0.36	1.75-3.24	6.78	< 0.001
12 months Follow-up	2.3 ± 0.20	6.1 ± 0.80	0.16	3.47-4.13	23.04	< 0.001
24 months Follow-up	2.4 ± 0.88	6.2 ± 1.1	0.27	3.25-4.34	13.97	< 0.001

Independent t-test.

Table 3 International Knee Documentation Committee score in various time-points

Time-point	Group A (n = 23)	Group B (n = 24)	Standard error	95%CI	t	P value
Pre-procedure	33.4 ± 10.20	36.7 ± 9.17	2.743	-2.22-8.82	1.20	0.23
1 month Follow-up	58.14 ± 17.23	56.6 ± 18.25	5.02	-11.63-8.55	-0.307	0.76
3 months Follow-up	60.3 ± 14.21	54.2 ± 13.25	3.88	-13.91-1.71	-1.57	0.12
6 months Follow-up	62.6 ± 13.27	50.16 ± 12.35	3.62	-19.72 to -5.15	-3.431	0.001
12 months Follow-up	78.3 ± 12.24	48.76 ± 12.17	3.45	-36.48 to -22.59	-8.56	< 0.001
24 months Follow-up	83.10 ± 18.25	45.16 ± 12.35	4.40	-46.80 to -29.07	-8.61	< 0.001

Independent t-test.

Table 4 Magnetic resonance observation of cartilage repair tissue 2.0 knee score at baseline and 24-month follow-up

Time-point	Group A (n = 23)	Group B (n = 24)	Standard error	95%CI	t	P value
Baseline	52.7 ± 6.2	53.3 ± 4.7	1.60	-2.62-3.82	0.37	0.71
24 months follow-up	91.8 ± 5.1	61.2 ± 8.4	2.03	-34.70 to -26.49	-15.01	< 0.001