Meta-Analysis
Copyright ©The Author(s) 2024.
World J Orthop. Jan 18, 2024; 15(1): 73-93
Published online Jan 18, 2024. doi: 10.5312/wjo.v15.i1.73
Table 1 Characteristics of the 28 included meta-analysis studies
Ref.
Last search
Study design
Number of included studies
Sample size
Intervention
Reference
Outcome
Putananon et al[37], 2018February, 2017RCT141201PA/LA/DAA/PA2PAHHS, VAS, complications
Higgins et al[6], 2015February, 2014RCT & nRCT172302PA/DAAPAHHS, VAS, blood loss, intra-operative fracture, operative time, length of hospital stay, dislocation
Miller et al[34], 2018June, 2017RCT & nRCT131044PA/DAAPAHHS, dislocation, intra-operative fracture, wound infection
Wang et al[44], 2018June, 2018RCT9754PA/DAAPAHHS, VAS, incision length, operative time, length of hospital stay, operative blood loss, intra-operative fracture, dislocation
Miller et al[35], 2018June, 2017RCT7609PA/DAAPAIncision length, length of hospital stay, operative time, operative blood loss, pain score, complication
Kucukdurmaz et al[30], 2019January, 2018RCT & nRCT17/11543PA/LA/DAAPAHHS, operative time, incision length, VAS, neurapraxia, intra-operative fracture, wound infection, dislocation
Jia et al[28], 2019August, 2016RCT & nRCT4/167377PA/DAAPAHHS, length of hospital stay, operative time, VAS, dislocation, neurapraxia, intra-operative fracture
Wang et al[43], 2019October, 2018RCT5475LA/DAALAHHS, VAS, operative time, operative blood loss, length of hospital stay, complication
Migliorini et al[32], 2021September, 2019RCT & nRCT20/3910675PA/LA/DAAPADislocation, nerve injury, revision
Migliorini et al[33], 2020October, 2019RCT & nRCT13/234383PA/LA/DAAPALength of hospital stay, operative time, operative blood loss
Cha et al[22], 2020October, 2019RCT8673PA/LA/DAAPAOperative time, Operative blood loss
Peng et al[36], 2020November, 2019RCT7600PA/DAAPAHHS, VAS, operative time, operative blood loss, length of hospital stay, incision length
Docter et al[24], 2020June, 2019RCT & nRCT19/50283036PA/LA/DAAPADislocation, intra-operative fracture, infection
Yang et al[45], 2020June, 2019RCT11932PA/DAAPAVAS, neurapraxia, intra-operative fracture, infection, dislocation, operative time, operative blood loss, length of hospital stay
Chen et al[23], 20202020RCT & nRCT4 /1434873PA/DAAPAHHS, VAS, operative time, operative blood loss, length of hospital stay, dislocation, intra-operative fracture
Sun et al[42], 2021June, 2019RCT & nRCT3 /622698PA/DAAPAHHS, operative time, operative blood loss, length of hospital stay, complication
Awad et al[21], 20212021RCT & nRCT7/228576PA/DAAPAHHS, operative time, operative blood loss, length of hospital stay, complication
Huerfano et al[27], 20212021RCT & nRCT5/207172PA/DAA/PADislocation
Gazendam et al[25], 20222021RCT252339PA/LA/ALA/DAAPAHHS, VAS, length of hospital stay, complication
Ge et al[26], 20212021RCT & nRCT3/3526DSA/SuperPath/PAPAHHS, operative time, operative blood loss, incision length, VAS, length of hospital stay
Joseph et al[29], 20232022RCT7730DSA/SuperPath/PAPAHHS, operative time, operative blood loss, incision length, VAS, length of hospital stay, complication
Lazaru et al[31], 20212021RCT9998DAA/PAPAHHS, operative time, operative blood loss, incision length, VAS
O’connor et al[105], 20212021No RCT151872DAA/non-DAAPA, ALA, LAInfection
Ramadanov et al[39], 20212021RCT161392DSA/SuperPath/DAA/PAPAHHS, operative time, operative blood loss, incision length, VAS
Ramadanov et al[40], 20212021RCT242074DSA/SuperPath/DAA/PAPAHHS, operative time, operative blood loss, incision length, VAS, complication
Ramadanov et al[41], 20222022RCT201501SuperPath/DAA/PAPAHHS, operative time, operative blood loss, incision length
Ramadanov et al[38], 20222022RCT141021SuperPath/PAPAHHS, operative time, operative blood loss, incision length, VAS, complication
Zhou et al[46], 20222022RCT151450DAA/PA/LAPA, LAHHS, operative time, length of hospital stay, complication
Ang et al[20], 20232023RCT242010DAA/LA/PAPAHHS, operative time, length of hospital stay, complication
Table 2 Characteristics of included 47 randomized controlled trials
Ref.
Country
Mean age
BMI
Male (%)
ASA
F/U (wk)
Diagnosis (% OA)
Intervention
Li et al[68], 2021China76.3522.8553.13NRNRNRDSA/SuperPath vs PA
Ulivi et al[18], 2021Italy72.9823.5137.78NR26NRDSA/SuperPath vs PA
Meng et al[19], 2021China64.9023.0942.502.3552NRDSA/SuperPath vs PA
Rykov et al[84], 2021Netherlands62.5028.2041.301.5952NRDAA vs PA
Cao et al[56], 2020China61.9024.9042.31NR26NRDAA vs PA
Nistor et al[76], 2020Romania62.6328.1541.07NR52NRDAA vs LA
Meng et al[73], 2019China51.0021.49100.001.6652NRDSA/SuperPath vs PA
Wang et al[91], 2019China55.3923.0959.26NR52100.00LA vs PA
Moerenhout et al[75], 2020Switzerland69.6627.1052.731.90260NRDAA vs PA
Li et al[67], 2019China62.0023.2673.33NR2642.00DAA vs LA
Bon et al[54], 2019France68.1226.5844.00NRNR100.00DAA vs PA
Ouyang et al[78], 2018China56.0023.1970.832.21NR20.83DSA/SuperPath vs PA
Zomar et al[97], 2018Canada60.1129.7352.56NR12100.00DAA vs LA
Taunton et al[88], 2018United States64.5129.4851.00NR52100.00DAA vs PA
Brismar et al[55], 2018Sweden66.7526.8835.001.61NR51.00DAA vs LA
Reichert et al[81], 2018Germany62.5828.20NRNRNR100.00DAA vs LA
Takada et al[86], 2018Japan62.6024.4013.33NRNR100.00DAA vs LA
Xie et al[93], 2017China65.5423.8466.30NR52100.00DSA/SuperPath vs PA
Cheng et al[57], 2017Australia61.2828.0145.201.9612100.00DAA vs PA
Xu et al[94], 2017China58.2724.4960.92NRNRNRDAA vs PA
Nistor et al[77], 2017Romania63.7528.0440.00NRNR100.00DAA vs LA
Rosenlund et al[83], 2017Denmark61.0327.5165.001.3252NRLA vs PA
Rykov et al[85], 2017NetherlandsNRNRNRNRNR84.80DAA vs PA
Zhao et al[96], 2017China63.53NRNRNRNRNRDAA vs PA
Anta-Díaz et al[59], 2016Spain64.1426.7552.52NR52100.00DAA vs LA
Parvizi et al[79], 2016United StatesNRNRNRNRNR100.00DAA vs LA
Luo et al[69], 2016ChinaNRNRNRNRNRNRLA vs PA
Christensen et al[58], 2015United States64.7130.7847.10NRNRNRDAA vs PA
Mjaaland et al[74], 2015Norway66.4227.6533.501.85NR100.00DAA vs LA
Vicente et al[90], 2015Brazil55.9427.3855.36NR2452.68LA vs PA
Dienstknecht et al[61], 2014Germany61.5329.1444.062.26NR100.00DAA vs LA
Taunton et al[87], 2014United States64.2328.4546.30NR52NRDAA vs PA
Landgraeber et al[66], 2013Germany70.6626.9034.212.06156100.00LMIS vs LA
Barrett et al[53], 2013United States62.3129.8955.20NR52NRDAA vs PA
Ji et al[65], 2012S. Korea51.4924.3057.10NR15037.20LA vs PA
Martin et al[70], 2011Belgium64.9230.0031.332.1452MostLMIS vs LA
Goosen et al[63], 2011Netherlands62.0026.4548.30NRNRNRLA vs PA
Pospischill et al[80], 2010Austria61.2525.7050.00NR12100.00LMIS vs LA
Yang et al[95], 2010China57.7822.7750.91NRNR20LA vs PA
Della Valle et al[60], 2010United States62.4627.4531.902.06NR100.002-incision vs PA
Restrepo et al[82], 2010United States59.9525.1839.392.13NRNRDAA vs LA
Mayr et al[71], 2009Switzerland68.0227.9942.42NRNRNRDAA vs LA
Meneghini et al[72], 2009United States54.0026.00NRNRNRNR2-incision vs LA vs PA
Witzleb et al[92], 2009Germany55.8827.7548.33NR1256.70LA vs PA
Yan et al[89], 2017China65.4223.9746.10NR60NRSuperPath vs LA
Yuan et al[64], 2018China75.0322.5455.56NR72NRSuperPath vs PA
Dongwei et al[62], 2016China58.21NRNRNR12100.00SuperPath vs LA
Table 3 Network meta-analysis results of primary outcomes
Risk ratio/unstandardized mean difference (95%CI)

PA
LA
DAA
2-incision
LMIS
DSA/SuperPath
HHS ≤ 3 mo
PA[27.4; 0.0]0.74 (-2.24, 3.72)3.49 (0.98, 6.00)0.83 (-7.50, 9.16)0.02 (-10.13, 10.17)1.57 (-1.55, 4.69)
LA-0.74 (-3.72, 2.24)[42.7; 0.5]2.75 (-0.02, 5.52)0.09 (-8.64, 8.81)-0.72 (-10.43, 8.99)0.83 (-2.91, 4.57)
DAA-3.49 (-6.00, -0.98)-2.75 (-5.52, 0.02)[85.9; 47.5]-2.66 (-11.31, 5.99)-3.47 (-13.56, 6.63)-1.92 (-5.67, 1.83)
2-incision-0.81 (-13.86, 12.24)-0.09 (-8.81, 8.64)2.66 (-5.99, 11.31)[45.5; 20.7]-0.81 (-13.86, 12.24)0.74 (-8.12, 9.61)
LMIS-0.02 (-10.17, 10.13)0.72 (-8.99, 10.43)3.47 (-6.63, 13.56)0.81 (-12.24, 13.86)[41.0; 22.1]1.55 (-8.85, 11.95)
DSA/SuperPath-1.57 (-4.69, 1.55)-0.83 (-4.57, 2.91)1.92 (-1.83, 5.67)-0.74 (-9.61, 8.12)-1.55 (-11.95, 8.85)[57.6; 9.2]
HHS 6 mo
PA[42.2; 3.0]-0.21 (-1.67, 1.25)0.22 (-0.95, 1.39)1.85 (-14.14, 17.84)NR0.35 (-0.84, 1.53)
LA0.21 (-1.25, 1.67)[33.2; 4.1]0.43 (-1.50, 2.36)2.06 (-13.94, 18.05)NR0.55 (-0.88, 1.98)
DAA-0.22 (-1.39, 0.95)-0.43 (-2.36, 1.50)[55.9; 19.3]1.63 (-14.41, 17.67)NR0.13 (-1.62, 1.87)
2-incision-1.85 (-17.84, 14.14)-2.06 (-18.05, 13.94)-1.63 (-17.67, 14.41)[57.6; 55.2]NR-1.50 (-17.52, 14.51)
LMISNRNRNRNRNRNR
DSA/SuperPath-0.35 (-1.53, 0.84)-0.55 (-1.98, 0.88)-0.13 (-1.87, 1.62)1.50 (-14.51, 17.52)NR[61.1; 18.4]
HHS 1 yr
PA[27.5; 0.0]0.60 (-0.55, 1.74)1.76 (1.12, 2.40)-1.93 (-4.95, 1.08)1.43 (-2.16, 5.02)0.42 (-0.28, 1.12)
LA-0.60 (-1.74, 0.55)[54.8; 0.0]1.17 (0.20, 2.14)-2.53 (-5.75, 0.69)0.83 (-2.57, 4.23)-0.18 (-1.52, 1.17)
DAA-1.76 (-2.40, -1.12)-1.17 (-2.14, -0.20)[90.7; 55.4]-3.70 (-6.78, -0.62)-0.34 (-3.87, 3.20)-1.34 (-2.29, -0.39)
2-incision1.93 (-1.08, 4.95)2.53 (-0.69, 5.75)3.70 (0.62, 6.78)[6.0; 0.6]3.36 (-1.32, 8.04)2.35 (-0.74, 5.45)
LMIS-1.43 (-5.02, 2.16)-0.83 (-4.23, 2.57)0.34 (-3.20, 3.87)-3.36 (-8.04, 1.32)[70.8; 43.7]-1.01 (-4.66, 2.65)
DSA/SuperPath-0.42 (-1.12, 0.28)0.18 (-1.17, 1.52)1.34 (0.39, 2.29)-2.35 (-5.45, 0.74)1.01 (-2.65, 4.66)[50.2; 0.3]
Dislocation
PA[50.8; 8.6]1.01 (0.34, 2.97)0.90 (0.52, 1.57)NR1.00 (0.08, 11.81)1.28 (0.29, 5.57)
LA0.99 (0.34, 2.94)[49.8; 15.2]0.90 (0.29, 2.74)NR0.99 (0.11, 9.14)1.27 (0.20, 7.90)
DAA1.11 (0.64, 1.92)1.11 (0.37, 3.40)[61.5; 21.9]NR1.11 (0.09, 13.27)1.41 (0.29, 6.82)
2-incisionNRNRNRNRNRNR
LMIS1.00 (0.08, 11.85)1.01 (0.11, 9.28)0.90 (0.08, 10.85)NR[50.9; 37.3]1.28 (0.07, 22.70)
DSA/SuperPath0.78 (0.18, 3.42)0.79 (0.13, 4.90)0.71 (0.15, 3.41)NR0.78 (0.04, 13.88)[37.2; 17.0]
Intra-operative fracture
PA[67.3; 17.2]1.33 (0.49, 3.58)0.96 (0.36, 2.57)1.84 (0.19, 18.35)2.19 (0.22, 21.84)1.75 (0.37, 8.35)
LA0.75 (0.28, 2.02)[49.0; 6.6]0.72 (0.26, 1.95)1.39 (0.12, 15.36)1.65 (0.21, 13.12)1.31 (0.21, 8.36)
DAA1.05 (0.39, 2.82)1.39 (0.51, 3.78)[70.7; 30.3]1.93 (0.17, 22.48)2.29 (0.23, 22.94)1.83 (0.29, 11.65)
2-incision0.54 (0.05, 5.39)0.72 (0.07, 8.00)0.52 (0.04, 6.03)[41.5; 19.9]1.19 (0.05, 28.49)0.95 (0.06, 15.27)
LMIS0.46 (0.05, 4.55)0.61 (0.08, 4.84)0.44 (0.04, 4.36)0.84 (0.04, 20.20)[33.6; 15.1]0.80 (0.05, 12.88)
DSA/SuperPath0.57 (0.12, 2.73)0.76 (0.12, 4.84)0.55 (0.09, 3.47)1.05 (0.07, 16.97)1.25 (0.08, 20.20)[37.9; 10.9]
Table 4 Network meta-analysis results of secondary outcomes
Risk ratio/Unstandardized mean difference (95%CI)

PA
LA
DAA
2 incisions
LMIS
DSA/SuperPath
Operative time
PA[98.6; 93.2]10.38 (2.04, 18.71)15.38 (8.64, 22.12)21.00 (-4.27, 46.27)23.86 (4.25, 43.47)18.74 (9.69, 27.79)
LA-10.38 (-18.71, -2.04)[70.7; 0.7]5.01 (-2.66, 12.68)10.62 (-15.99, 37.24)13.49 (-4.26, 31.23)8.36 (-3.12, 19.84)
DAA-15.38 (-22.12, -8.64)-5.01 (-12.68, 2.66)[46.0; 0.0]5.62 (-20.54, 31.78)8.48 (-10.86, 27.81)3.35 (-7.58, 14.29)
2-incision-21.00 (-46.27, 4.27)-10.62 (-37.24, 15.99)-5.62 (-31.78, 20.54)[33.8; 5.3]2.86 (-29.13, 34.85)-2.26 (-29.11, 24.58)
LMIS-23.86 (-43.47, -4.25)-13.49 (-31.23, 4.26)-8.48 (-27.81, 10.86)-2.86 (-34.85, 29.13)[19.6; 0.8]-5.12 (-26.26, 16.01)
DSA/SuperPath-18.74 (-27.79, -9.69)-8.36 (-19.84, 3.12)-3.35 (-14.29, 7.58)2.26 (-24.58, 29.11)5.12 (-16.01, 26.26)[31.4; 0.0]
Length of hospital stay
PA[45.5; 0.0]0.52 (-0.36, 1.39)-0.21 (-0.84, 0.43)0.11 (-1.29, 1.51)0.32 (-2.12, 2.76)-1.56 (-2.44, -0.69)
LA-0.52 (-1.39, 0.36)[16.9; 0.0]-0.72 (-1.52, 0.07)-0.41 (-1.92, 1.10)-0.20 (-2.48, 2.08)-2.08 (-3.12, -1.04)
DAA0.21 (-0.43, 0.84)0.72 (-0.07, 1.52)[61.3; 0.7]0.31 (-1.17, 1.80)0.52 (-1.89, 2.94)-1.36 (-2.36, -0.35)
2-incision-0.11 (-1.51, 1.29)0.41 (-1.10, 1.92)-0.31 (-1.80, 1.17)[42.6; 3.0]0.21 (-2.52, 2.94)-1.67 (-3.28, -0.06)
LMIS-0.32 (-2.76, 2.12)0.20 (-2.08, 2.48)-0.52 (-2.94, 1.89)-0.21 (-2.94, 2.52)[35.8; 6.3]-1.88 (-4.38, 0.62)
DSA/SuperPath1.56 (0.69, 2.44)2.08 (1.04, 3.12)1.36 (0.35, 2.36)1.67 (0.06, 3.28)1.88 (-0.62, 4.38)[97.9; 90.0]
Incision length
PA[4.0; 0.0]-1.53 (-3.86, 0.81)-2.54 (-4.64, -0.45)NR-3.42 (-7.99, 1.16)-5.15 (-7.29, -3.01)
LA1.53 (-0.81, 3.86)[31.1; 0.0]-1.02 (-3.00, 0.96)NR-1.89 (-5.82, 2.04)-3.62 (-6.52, -0.72)
DAA2.54 (0.45, 4.64)1.02 (-0.96, 3.00)[55.4; 1.8]NR-0.87 (-5.27, 3.53)-2.60 (-5.45, 0.24)
2-incisionNRNRNRNRNRNR
LMIS3.42 (-1.16, 7.99)1.89 (-2.04, 5.82)0.87 (-3.53, 5.27)NR[66.5; 24.5]-1.73 (-6.62, 3.16)
DSA/SuperPath5.15 (3.01, 7.29)3.62 (0.72, 6.52)2.60 (-0.24, 5.45)NR1.73 (-3.16, 6.62)[92.9; 73.7]
Operative blood loss
PA[61.6; 10.7]-25.66 (-117.26, 65.95)23.03 (-56.18, 102.24)46.00 (-185.02, 277.02)59.67 (-177.38, 296.72)23.02 (-56.58, 102.62)
LA25.66 (-65.95, 117.26)[75.9; 35.1]48.69 (-47.77, 145.15)71.66 (-176.86, 320.18)85.33 (-133.30, 303.96)48.68 (-62.19, 159.55)
DAA-23.03 (-102.24, 56.18)-48.69 (-145.15, 47.77)[44.0; 5.6]22.97 (-221.26, 267.19)36.64 (-202.33, 275.61)-0.01 (-108.84, 108.82)
2-incision-46.00 (-277.02, 185.02)-71.66 (-320.18, 176.86)-22.97 (-267.19, 221.26)[41.9; 24.3]13.67 (-317.33, 344.68)-22.98 (-267.33, 221.37)
LMIS-59.67 (-296.72, 177.38)-85.33 (-303.96, 133.30)-36.64 (-275.61, 202.33)-13.67 (-344.68, 317.33)[34.4; 17.5]-36.65 (-281.79, 208.49)
DSA/SuperPath-23.02 (-102.62, 56.58)-48.68 (-159.55, 62.19)0.01 (-108.82, 108.84)22.98 (-221.37, 267.33)36.65 (-208.49, 281.79)[42.2; 6.8]
Wound complication
PA[70.0; 16.2]2.26 (0.72, 7.06)1.31 (0.59, 2.88)0.80 (0.04, 18.03)5.45 (0.60, 49.61)1.00 (0.15, 6.79)
LA0.44 (0.14, 1.38)[31.0; 0.9]0.58 (0.18, 1.87)0.36 (0.02, 7.11)2.41 (0.36, 16.00)0.44 (0.05, 4.11)
DAA0.77 (0.35, 1.69)1.73 (0.53, 5.62)[54.8; 5.2]0.62 (0.03, 14.29)4.18 (0.45, 38.77)0.77 (0.10, 6.09)
2-incision1.24 (0.06, 27.95)2.81 (0.14, 56.24)1.62 (0.07, 37.72)[68.8; 46.2]6.79 (0.20, 234.54)1.24 (0.03, 48.08)
LMIS0.18 (0.02, 1.67)0.41 (0.06, 2.75)0.24 (0.03, 2.22)0.15 (0.00, 5.09)[12.5; 1.3]0.18 (0.01, 3.41)
DSA/SuperPath1.00 (0.15, 6.79)2.26 (0.24, 20.99)1.31 (0.16, 10.38)0.80 (0.02, 31.03)5.45 (0.29, 101.44)[62.8; 30.2]
Nerve injury
PA[79.7; 25.6]2.97 (0.89, 9.97)9.82 (3.06, 31.58)18.97 (2.41, 149.62)1.08 (0.11, 10.20)1.00 (0.02, 49.35)
LA0.34 (0.10, 1.13)[49.4; 0.5]3.30 (1.22, 8.94)6.38 (0.81, 50.31)0.36 (0.05, 2.41)0.34 (0.01, 19.93)
DAA0.10 (0.03, 0.33)0.30 (0.11, 0.82)[17.9; 0.0]1.93 (0.22, 16.92)0.11 (0.01, 0.93)0.10 (0.00, 5.96)
2-incision0.05 (0.01, 0.42)0.16 (0.02, 1.24)0.52 (0.06, 4.54)[9.0; 0.2]0.06 (0.00, 0.94)0.05 (0.00, 4.35)
LMIS0.93 (0.10, 8.81)2.76 (0.41, 18.42)9.13 (1.07, 77.77)17.63 (1.07, 291.08)[75.1; 31.9]0.93 (0.01, 83.77)
DSA/SuperPath1.00 (0.02, 49.35)2.97 (0.05, 176.30)9.82 (0.17, 575.31)18.97 (0.23, 1564.11)1.08 (0.01, 97.00)[69.0; 41.8]