Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia

Table 1 Main characteristics of the study population, n (%)

	Knee osteoarthritis (n = 824)	Hip osteoarthritis (n = 278)	All (n = 1102)
Age, (yr), mean (SD)	60.4 (6.9)	60.3 (7.2)	60.4 (7.0)
Gender
Female	728 (88.3)	240 (86.3)	968 (87.8)
Male	96 (11.7)	38 (13.7)	134 (12.2)
Ethnicity
Caucasian	820 (99.5)	278 (100.0)	1098 (99.6)
Black	1 (0.1)	0	1 (0.1)
Asian	3 (0.4)	0	3 (0.3)
BMI, mean (SD)	29.77 (5.5)	28.66 (5.3)	29.49 (5.5)
Scale of stages of osteoarthritis according to Kellgren & Lawrence
Stage 1	81 (9.8)	35 (12.6)	116 (10.5)
Stage 2	617 (74.9)	211 (75.9)	828 (75.1)
Stage 3	125 (15.2)	32 (11.5)	157 (14.2)
No data available	1 (0.1)		1 (0.1)

BMI: Body mass index.

Table 2 Change in Knee Injury and Osteoarthritis Outcome Score subscale scores (Full analysis set)

Subscale	Knee osteoarthritis (n = 824) – KOOS scale					P valuea
	Visit 1, baseline, n = 824	Visit 2, week 16-24, n = 798	Visit 3 week 36-44, n = 794	Visit 4, week 56-64, n = 794	Changes from baseline on visit 4
Pain	61.48 (60.36-62.61)	79.59 (78.48-80.70)	82.50 (81.45-83.56)	84.24 (83.15-85.34)	22.87 (21.56-24.18)	< 0.001
Symptoms	62.25 (61.02-63.48)	77.65 (76.46-78.84)	81.09 (79.97-82.21)	82.80 (81.66-83.93)	20.78 (19.43-22.13)	< 0.001
Functional activity of the joint	61.46 (60.73-62.18)	72.48 (71.63-73.34)	75.78 (74.86-76.69)	78.03 (77.06-78.99)	16.60 (15.59-17.61)	< 0.001
Quality of life	44.99 (43.83-46.16)	61.40 (60.10-62.69)	65.91 (64.54-67.27)	69.92 (68.45-71.39)	24.87 (23.41-26.34)	< 0.001

^awith Holm-Bonferroni method. Mean data are presented (95%CI). CI: Confidence interval; KOOS: Knee Injury and Osteoarthritis Outcome Score.

Table 3 Change in Hip disability and Osteoarthritis Outcome Score subscale scores (Full analysis set)

Subscale	Hip osteoarthritis (n = 278) – HOOS scale					P valuea
	Visit 1, baseline, n = 278	Visit 2, week 16-24, n = 272	Visit 3, week 36-44, n = 271	Visit 4, week 56-64, n = 270	Changes from baseline on visit 4
Pain	60.97 (58.93-63.02)	76.36 (74.34-78.38)	80.89 (78.95-82.84)	83.63 (81.64-85.62)	22.81 (20.47-25.16)	< 0.001
Symptoms	61.17 (59.08-63.26)	73.73 (71.62-75.84)	78.17 (76.21-80.14)	81.19 (79.21-83.16)	19.93 (17.49-22.36)	< 0.001
Functional activity of the joint	65.57 (63.62-67.52)	78.46 (76.72-80.21)	81.59 (79.93-83.26)	84.11 (82.45-85.76)	18.77 (16.61-20.93)	< 0.001
Quality of life	46.79 (44.72-48.85)	60.75 (58.50-63.01)	65.41 (63.09-67.72)	69.33 (66.83-71.82)	22.71 (20.14-25.28)	< 0.001

^awith Holm-Bonferroni method. Mean data are presented (95%CI). CI: confidence interval; HOOS: Hip disability and Osteoarthritis Outcome Score (HOOS).